文献类型：期刊文献

英文题名：Mitochondria-targeted ratiometric fluorescent probes for micropolarity and microviscosity and their applications

作者：Cui, Jingjing[1];Yao, Yuhua[1];Chen, Cong[1];Huang, Rui[1];Zhang, Weibing[1];Qian, Junhong[1]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Shanghai Key Lab Funct Mat Chem, Shanghai 200237, Peoples R China

年份：2019

卷号：30

期号：5

起止页码：1071

外文期刊名：CHINESE CHEMICAL LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000469156300032)】；

基金：The authors acknowledge the National Natural Science Foundation of China (No. 21576085) for financial support.

语种：英文

外文关键词：Fluorescent probe; Mitochondria; Microviscosity; Micropolarity

摘要：Two fluorescent "off-on" probes YYH1 and YYH2 were used for the detection of mitochondrial polarity and viscosity. Both probes have two emission bands: The peak of shorter wavelength was sensitive to the polarity, while that in longer wavelength region was sensitive to the viscosity, which enables us to detect medium polarity and viscosity simultaneously. The lg(I-short/I-long) of YYH1 exhibited linear relationship to the solvent polarity, while that of YYH2 was closely related to the solvent viscosity. Furthermore, both probes showed potential in bioimaging mitochondrial polarity or viscosity in living cells. (C) 2019 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.