文献类型：期刊文献

英文题名：Uniting Dual-Modal MRI/Chemiluminescence Nanotheranostics: Spatially and Sensitively Self-Reporting Photodynamic Therapy in Oral Cancer

作者：Tao, Yining[1,2];Yan, Chenxu[2];Wu, Yue[3];Li, Dan[2];Li, Juan[2];Xie, Yuchen[4];Cheng, Yingsheng[1,5];Xu, Yisheng[3];Yang, Kai[1,5];Zhu, Wei-Hong[2];Guo, Zhiqian[2]

机构：[1]Shanghai Jiao Tong Univ, Dept Intervent Radiol, Shanghai Peoples Hosp 6, Sch Med, Shanghai 200233, Peoples R China;[2]East China Univ Sci & Technol, Sch Chem & Mol Engn, Key Lab Adv Mat, Joint Int Res Lab Precis Chem & Mol Engn,State Key, Shanghai 200237, Peoples R China;[3]East China Univ Sci & Technol, State Key Lab Chem Engn, Shanghai 200237, Peoples R China;[4]Mem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, New York, NY 10065 USA;[5]Tongji Hosp, Dept Imaging Med & Nucl Med, Shanghai 200065, Peoples R China

年份：2023

卷号：33

期号：40

外文期刊名：ADVANCED FUNCTIONAL MATERIALS

收录：;EI(收录号：20232314181598);WOS:【SCI-EXPANDED(收录号:WOS:001000054500001)】；

基金：This work was supported by the NSFC/China (22225805 and 32121005), the National Key Research and Development Program (2021YFA0910000), the Innovation Program of Shanghai Municipal Education Commission, Shanghai Frontier Science Research Base of Optogenetic Techniques for Cell Metabolism (Shanghai Municipal Education Commission, grant 2021 Sci & Tech 03-28), the Shanghai Municipal Science and Technology Major Project (Grant 2018SHZDZX03), the Shanghai Science and Technology Committee Rising-Star Program (22QC1400400), and the Programme of Introducing Talents of Discipline to Universities (B16017).

语种：英文

外文关键词：chemiluminescence probes; flash nanoprecipitation; fluorescence; magnetic resonance imaging; photodynamic therapy

摘要：Unpredictable in vivo therapeutic feedback of reactive oxygen species (ROS) efficiency is the major bottleneck of photodynamic therapy (PDT). Herein, novel PDT-based nanotheranostics Pa-Mn&CH-A@P are elaborately constructed for in vivo tracking biodistribution and in situ self-reporting PDT, which innovatively unites magnetic resonance imaging (MRI) and chemiluminescence (CL) signals. Taking advantages of the versatility of lanthanide coordination chemistry and flash nanoprecipitation (FNP) technology, photosensitizers, MRI, and CL agents are unprecedently integrated within a stable and uniform nanotheranostic. Specifically, MRI signal offers detailed dose distribution of nanotheranostics with high-spatial resolution, and CL signal timely performs in situ evaluation of ROS generation with high sensitivity. This dual-modal MRI/CL nanotheranostic makes a breakthrough in high fidelity feedback for oral tumor, conquering the inherent unpredictable obstacles on spatially and sensitively reporting PDT.