文献类型：期刊文献

英文题名：Recent advances in the microbial synthesis of lactate-based copolymer

作者：Guo, Pengye[1];Luo, Yuanchan[1];Wu, Ju[1];Wu, Hui[1,2,3]

机构：[1]East China Univ Sci & Technol, Sch Biotechnol, State Key Lab Bioreactor Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]Shanghai Collaborat Innovat Ctr Biomfg, 130 Meilong Rd, Shanghai 200237, Peoples R China;[3]China Natl Light Ind Council, Key Lab Biobased Mat Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China

年份：2021

卷号：8

期号：1

外文期刊名：BIORESOURCES AND BIOPROCESSING

收录：;EI(收录号：20224513077423);WOS:【SCI-EXPANDED(收录号:WOS:000710139700003)】；

基金：The National Natural Science Foundation of China (Grant No. 21776083), the National Key Research and Development Program of China (Grant No. 2017YFB0309302), the Science and Technology Commission of Shanghai Municipality (Grant No. 21DZ1209100), the Fundamental Research Funds for the Central Universities (Grant No. 22221818014), the 111 Project (B18022).

语种：英文

外文关键词：Lactate-based copolymer; P(LA-co-3HB); Microbial synthesis; Production strategy

摘要：Due to the increasing environmental pollution of un-degradable plastics and the consumption of non-renewable resources, more attention has been attracted by new bio-degradable/based polymers produced from renewable resources. Polylactic acid (PLA) is one of the most representative bio-based materials, with obvious advantages and disadvantages, and has a wide range of applications in industry, medicine, and research. By copolymerizing to make up for its deficiencies, the obtained copolymers have more excellent properties. The development of a one-step microbial metabolism production process of the lactate (LA)-based copolymers overcomes the inherent shortcomings in the traditional chemical synthesis process. The most common lactate-based copolymer is poly(lactate-co-3-hydroxybutyrate) [P(LA-co-3HB)], within which the difference of LA monomer fraction will cause the change in the material properties. It is necessary to regulate LA monomer fraction by appropriate methods. Based on synthetic biology and systems metabolic engineering, this review mainly focus on how did the different production strategies (such as enzyme engineering, fermentation engineering, etc.) of P(LA-co-3HB) optimize the chassis cells to efficiently produce it. In addition, the metabolic engineering strategies of some other lactate-based copolymers are also introduced in this article. These studies would facilitate to expand the application fields of the corresponding materials.