文献类型：期刊文献

英文题名：Synthesis of β-C-glycopyranosyl-1,4-naphthoquinone derivatives and their cytotoxic activity

作者：Lin, Li[1,2]; He, Xiao-Peng[1]; Xu, Qing[1]; Chen, Guo-Rong[1]; Xie, Juan[2]

机构：[1] Laboratory for Advanced Materials, Institute of Fine Chemicals, East China University of Science and Technology, Shanghai, 200237, China; [2] PPSM, ENS Cachan, CNRS, UniverSud, 61 av President Wilson, F-94230 Cachan, France

年份：2008

卷号：343

期号：4

起止页码：773

外文期刊名：Carbohydrate Research

收录：EI(收录号：20080911124064)

语种：英文

外文关键词：Cytotoxicity - Derivatives - Reaction rates - Substitution reactions - Synthesis (chemical)

摘要：β-C-Glucosyl and β-C-galactosyl-1,4-dimethoxynaphthalenes have been synthesized using a F3CCO2Ag/SnCl4 promoted Friedel-Crafts electrophilic substitution reaction. Both glycosyl acetates and methyl glycosides can be used as glycosyl donors. Further oxidation afforded the corresponding β-C-glycosyl-1,4-naphthoquinones. The in vitro cytotoxic activity of these compounds was evaluated against the A375 cell line. ? 2007 Elsevier Ltd. All rights reserved.