文献类型：期刊文献

英文题名：Therapeutic deep eutectic solvents based on natural product matrine and caprylic acid: Physical properties, cytotoxicity and formation of surfactant free microemulsion

作者：Li, Menghan[1];Yuan, Jing[2];Yang, Qinghua[1];Liu, Zhuoni[1];Meng, Shengxi[2];Wang, Xiaoyong[1];Peng, Changjun[1];Yin, Tianxiang[1]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Shanghai 200237, Peoples R China;[2]Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 6, Sch Med, Shanghai 200233, Peoples R China

年份：2023

卷号：90

外文期刊名：JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001127701000001)】；

基金：This work was supported by the National Natural Science Foundation of China (Projects 21773063, 22273022) .

语种：英文

外文关键词：Matrine; Caprylic acid; Cytotoxicity; Surfactant free microemulsion

摘要：Deep eutectic solvents (DESs), as a new type of green solvent, have drawn much attention in various fields. DESs constructed from active pharmaceutical ingredients (APIs), termed as therapeutic deep eutectic solvent (THEDES), have displayed great potential applications in pharmaceutic fields. In this work, a new type of THEDES based on matrine and caprylic acid was prepared. The physical properties like density, viscosity, and electric conductivity of THEDESs were measured at various matrine and caprylic acid ratios in the temperature range from 298.15 K to 333.15 K. Further analysis by Walden plot suggested the "poor ionic liquid" behavior of the THEDESs studied herein. Moreover, it has been shown that these THEDESs displayed slightly higher cytotoxicity than that of matrine. Moreover, surfactant free microemulsions (SFMEs) consisted of 1,2-propanediol (PG), isopropyl myristate (IPM) and THEDESs were constructed and characterized. It was further found that curcumin, a poorly soluble API, displayed much higher solubility and stability in this SFME as compared to these in commonly used solvents.