文献类型：期刊文献

英文题名：Microfluidic-Assisted Interfacial Polymerization for Continuous Fabrication of Biomimetic Microreactors

作者：Jiang, Minghao[1];Feng, Haoshi[1];Gao, Yuliang[1];Lin, Kehong[1];Chen, Xinyu[1];Wang, Xiaoyu[1];Wang, Yiming[1,2]

机构：[1]East China Univ Sci & Technol, Sch Chem Engn, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Shanghai Key Lab Intelligent Sensing & Detect Tech, Shanghai 200237, Peoples R China

年份：2026

卷号：65

期号：23

起止页码：12121

外文期刊名：INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH

收录：;EI(收录号：20262520934892);WOS:【SCI-EXPANDED(收录号:WOS:001786417300001)】；

基金：We acknowledge the financial support of Shanghai Pilot Program for Basic Research (22TQ1400100-9), the "Chenguang Program" supported by the Shanghai Education Development Foundation and Shanghai Municipal Education Commission (20CG36), and National Key Research and Development Program of China (2022YFD70050101).

语种：英文

外文关键词：Amides - Biomimetic processes - Emulsification - Emulsions - Fabrication - Living polymerization - Microfluidics - Monomers - Phase interfaces - Self assembly - Supramolecular chemistry

摘要：Inspired by the compartmentalized supramolecular structures in living cells for complex metabolic processes, many biomimetic compartmentalized structures including coacervates, emulsion microdroplets, liposomes, proteinosomes, and vesicles driven by non-covalent interactions have been created to serve as biomimetic microreactors. However, because of the intrinsic feature of non-covalent interactions, most of the biomimetic microreactors suffer from underwhelming stability. Here, we show continuous fabrication of robust biomimetic microreactors through microfluidic-assisted interfacial polymerization of polyamide acid (PAA). By distributing anhydride-based monomers and tris-hydrazide monomers in oil and water phases, respectively, PAA films are rapidly formed at the water-oil interface through the formation of amide bonds. By coupling the interfacial polymerization strategy with a microfluidic technique, together with a simple gelation of the encapsulated aqueous phase, robust microreactors protected by PAA films are continuously fabricated. The obtained microreactors show a uniform size of similar to 185 mu m and are found to be able to effectively load enzymes. As an application, an enzymatic self-assembly of supramolecular fibers in the microreactors that mimic the self-assembly of biological filaments inside living cells is demonstrated. This work may accelerate the scalable fabrication of stable biomimetic microreactors for conversion of chemicals.