文献类型：期刊文献

英文题名：A mesoporous MnO2-based nanoplatform with near infrared light-controlled nitric oxide delivery and tumor microenvironment modulation for enhanced antitumor therapy

作者：Zhang, Hai -Lin[1];Wang, Yi[1];Tang, Qi[1];Ren, Bing[1];Yang, Shi-Ping[2];Liu, Jin -Gang[1]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[2]Shanghai Normal Univ, Key Lab Resource Chem MOE & Shanghai Key Lab Rare, Shanghai 200234, Peoples R China

年份：2023

卷号：241

外文期刊名：JOURNAL OF INORGANIC BIOCHEMISTRY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000925405800001)】；

基金：This study was financially supported by the National Natural Science Foundation of China (No. 21571062) , the Program for Professor of Special Appointment (Eastern Scholar) at the Shanghai Institutions of Higher Learning to JGL, and the Fundamental Research Funds for the Central Universities (No. 222201717003) .

语种：英文

外文关键词：Tumor microenvironment modulation; Manganese dioxide; Ruthenium nitrosyl; Nitric oxide delivery; Fenton-like reaction; Synergistic therapy

摘要：A hollow mesoporous manganese dioxide-based (H-MnO2) multifunctional nanoplatform, H-MnO2 @AFIPB@PDA@Ru-NO@FA (MAPRF NPs), was prepared for synergistic cancer treatment, in which a histone deacetylase inhibitor AFIPB was loaded in its hollow cavity and a ruthenium nitrosyl donor (Ru-NO) and a folic acid (FA) targeting group were covalently decorated on its covered polydopamine (PDA) layer. The MAPRF NPs showed tumor microenvironment (TME)-responsive properties of depletion of glutathione (GSH) to disrupt the antioxidant defense system and on-demand drug delivery. And the released Mn2+ further catalyzed the decomposition of endogenous H2O2 to produce highly toxic hydroxyl radicals (center dot OH) for enhanced chemodynamic therapy (CDT). Furthermore, upon 808 nm light irradiation MAPRF NPs exhibited controlled nitric oxide (NO) delivery and simultaneously produced significant photothermal effect. Consequently, MAPRF NPs showed high mortality toward cancer cells in the presence of 808 nm light irradiation. This work provides a paradigm of multimodal synergistic therapy that combines NO-based gas therapy with TME modulation for efficient anti-tumor therapy.