文献类型：期刊文献

英文题名：Robust hierarchical porous MBG scaffolds with promoted biomineralization ability

作者：Xie, Peng[1];Du, Jiahui[2,3];Li, Yulin[1];Wu, Jingyao[1];He, Hongyan[1];Jiang, Xinquan[2,3];Liu, Changsheng[1]

机构：[1]East China Univ Sci & Technol, Sch Mat Sci & Engn, Minist Educ,Engn Res Ctr Biomed Mat, Key Lab Ultrafine Mat,State Key Lab Bioreactor En, Shanghai 200237, Peoples R China;[2]Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Sch Med,Natl Clin Res Ctr Oral Dis, Coll Stomatol,Dept Prosthodont,Shanghai Key Lab S, 639 Zhizaoju Rd, Shanghai 200011, Peoples R China;[3]Shanghai Res Inst Stomatol, 639 Zhizaoju Rd, Shanghai 200011, Peoples R China

年份：2019

卷号：178

起止页码：22

外文期刊名：COLLOIDS AND SURFACES B-BIOINTERFACES

收录：;EI(收录号：20190906566350);WOS:【SCI-EXPANDED(收录号:WOS:000471084400003)】；

基金：This research was supported by the National Key Research and Development Program of China (2017YFB0309300), the National Natural Science Foundation of China (81772317) and Shanghai Municipal "Hong Kong, Macao and Taiwan" Cooperation Program of Science and Technology (18490761100). The funding grant from the National Natural Science Foundation of China for Innovative Research Groups (No. 51621002) and Chinese Academy of Sciences-Wego Holding Co. Research and Development Program (Technological Project: [2017]005) were also acknowledged.

语种：英文

外文关键词：Nanofiber-enhanced scaffolds; Macro/micro/nano architecture; Biomimetic interface; Biomineralized acceleration; Bone regeneration

摘要：Although bioactive glasses have been traditionally used in the clinical practice for a long period, their uncontrollable architecture and poor mechanical robustness remains a neck bottle for further biomedical applications. In this study, we firstly developed a series of mesoporous bioactive glass (MBG) nanorods with different aspect ratios and adjustable pore sizes via a thermal-mediation approach. The nanorods were then dispersed in MBG sol, followed by impregnation with sponge and in situ gelation. After sinter treatment, the sponge template was removed to offer interconnected macroporous structure, while the intercross-linked MBG nanorods afford mesa- and micro-pores. The resulting scaffolds presented a 2-fold reinforcement in compressive strength (1.03 MPa) which is matchable to that of cancellous bone. When their mesopore size was tuned to 7.38 nm, the scaffolds enabled an optimal protein adsorption capacity and sustainable release property. Upon 3-day incubation in simulated body fluid, the scaffolds with macro/meso/micro porous structure present more needle like hydroxyapatites, indicating their promoted biomineralization capacity. After culture with rat bone marrow stromal cells for 1 day, the hierarchical porous scaffolds displayed good cell attachment and proliferation ability, suggesting their potential as a kind of scaffolds for tissue engineering.