文献类型：期刊文献

英文题名：Biocompatibility, degradability, bioactivity and osteogenesis of mesoporous/macroporous scaffolds of mesoporous diopside/poly(L-lactide) composite

作者：Liu, Zhulin[1];Ji, Jiajin[1];Tang, Songchao[1];Qian, Jun[1];Yan, Yonggang[2];Yu, Baoqing[3];Su, Jiacan[3];Wei, Jie[1]

机构：[1]E China Univ Sci & Technol, Minist Educ, Key Lab Ultrafine Mat, Shanghai Key Lab Adv Polymer Mat, Shanghai 200237, Peoples R China;[2]Sichuan Univ, Coll Phys Sci & Technol, Chengdu 610041, Peoples R China;[3]Second Mil Med Univ, Changhai Hosp, Dept Orthopaed, Shanghai 200433, Peoples R China

年份：2015

卷号：12

期号：111

外文期刊名：JOURNAL OF THE ROYAL SOCIETY INTERFACE

收录：;EI(收录号：20154501497217);WOS:【SCI-EXPANDED(收录号:WOS:000363487600007)】；

基金：This study was supported by grants from the National Natural Science Foundation of China (51173041,31271031), the National Science and Technology Support Plan Projects (no. 2012BAD32B01), the International Cooperation Project of the Ministry of Science and Technology of China (2013DFB50280), the Major International Joint Research Project between China and Korea (81461148033, 31311140253) and the Key Medical Programme of Science and Technology Development of Shanghai (12441902802).

语种：英文

外文关键词：mesoporous diopside; biocomposite; mesoporous/macroporous scaffolds; degradability; osteogenesis

摘要：Bioactive mesoporous diopside (m-DP) and poly(L-lactide) (PLLA) composite scaffolds with mesoporous/macroporous structure were prepared by the solution-casting and particulate-leaching method. The results demonstrated that the degradability and bioactivity of the mesoporous/macroporous scaffolds were significantly improved by incorporating m-DP into PLLA, and that the improvement was m-DP content-dependent. In addition, the scaffolds containing m-DP showed the ability to neutralize acidic degradation products and prevent the pH from dropping in the solution during the soaking period. Moreover, the scaffolds containing m-DP enhanced attachment, proliferation and alkaline phosphatase activity of MC3T3-E1 cells, which were also m-DP content-dependent. Furthermore, the histological and immunohistochemical analysis results showed that the scaffolds with m-DP significantly promoted new bone formation and improved the materials degraded in vivo, indicating goodbiocompatibility. The results suggested that the mesoporous/macroporous scaffolds of the m-DP/PLLA composite with osteogenesis had a potential for bone regeneration.