文献类型：期刊文献

英文题名：β-CATENIN IS REQUIRED FOR MAINTAINING HIPPOCAMPAL MORPHOLOGY DURING THE PERINATAL PERIOD

作者：Wang, H. -T.[1];Zeng, L.[1];Chen, Q.[1];Zhang, X.[1];Liu, J. -W.[1];Lu, T. -J.[2];Xiong, Z. -Q.[2];Zheng, J.[1];Hu, Z. -L.[1]

机构：[1]E China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China;[2]Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, Shanghai 200031, Peoples R China

年份：2015

卷号：284

起止页码：273

外文期刊名：NEUROSCIENCE

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000346243100025)】；

基金：The authors would like to thank Xue-wen Cheng for suggestions and providing antibodies in this research, and thank Bing Lu, Da-feng Xu and Kui Li for technical assistance. This work was supported by the Exploratory Research Foundation of ECUST to Zelan Hu, the 111 project (Grant number: B07023) and the Shanghai Committee of Science and Technology (Grant number: 11DZ2260600).

语种：英文

外文关键词：beta-catenin; hippocampal primordium; radial glial scaffold; ectopic cell; perinatal stage; GFAP

摘要：In mice, the compact hippocampal primordium is formed during the prenatal stage by early-generated neurons that migrate from the lateral ventricular zone. However, despite much being understood about the formation of the hippocampus, the molecular mechanisms that maintain the morphology of the hippocampal primordium after its formation remain to be characterized. beta-Catenin is a key factor of canonical Wnt signaling and also a component of adherens junctions. Previous embryonic deletion studies have demonstrated that beta-catenin is required for early development and generation of granule cells. However, whether beta-catenin is involved in the morphological maintenance of the hippocampus as a cell adhesion molecule is still unknown. Here, we report that perinatal deletion of beta-catenin in postmitotic neurons and some radial glial cells of hippocampus using CamKII alpha-iCre; beta-catenin(flox/flox) conditional knockout mice, leads to disorganization of the radial glial scaffold and consequentially severe defects in hippocampal morphology. We demonstrate that beta-catenin is required for maintaining radial glial scaffold possibly via its well-known role in cell adhesion during the perinatal period. These findings provide essential advances into our understanding of the maintenance of the hippocampal primordium during the perinatal period. (C) 2014 IBRO. Published by Elsevier Ltd. All rights reserved.