文献类型：期刊文献

英文题名：Optimization of microbial cell factories for astaxanthin production: Biosynthesis and regulations, engineering strategies and fermentation optimization strategies

作者：Basiony, Mostafa[1];Ouyang, Liming[1];Wang, Danni[1];Yu, Jiaming[1];Zhou, Liming[1];Zhu, Mohan[1];Wang, Xuyuan[1];Feng, Jie[1];Dai, Jing[1];Shen, Yijie[1];Zhang, Chengguo[2];Hua, Qiang[1];Yang, Xiuliang[2];Zhang, Lixin[1]

机构：[1]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[2]Shandong Jincheng Biopharmaceut Co Ltd, 117 Qixing River Rd, Zibo 255130, Shandong, Peoples R China

年份：2022

卷号：7

期号：2

起止页码：689

外文期刊名：SYNTHETIC AND SYSTEMS BIOTECHNOLOGY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000788634100005)】；

基金：We gratefully acknowledge the financial support from the National Key Research and Development Program of China (2020YFA0907800) and Shandong Jincheng Bio-Pharmaceutical Co., Ltd.

语种：英文

外文关键词：Astaxanthin; Carotenoids; Metabolic engineering; Microbial cell factories; Lipid; Fermentation; Antioxidants

摘要：The global market demand for natural astaxanthin is rapidly increasing owing to its safety, the potential health benefits, and the diverse applications in food and pharmaceutical industries. The major native producers of natural astaxanthin on industrial scale are the alga Haematococcus pluvialis and the yeast Xanthopyllomyces dendrorhous. However, the natural production via these native producers is facing challenges of limited yield and high cost of cultivation and extraction. Alternatively, astaxanthin production via metabolically engineered nonnative microbial cell factories such as Escherichia coli, Saccharomyces cerevisiae and Yarrowia lipolytica is another promising strategy to overcome these limitations. In this review we summarize the recent scientific and biotechnological progresses on astaxanthin biosynthetic pathways, transcriptional regulations, the interrelation with lipid metabolism, engineering strategies as well as fermentation process control in major native and nonnative astaxanthin producers. These progresses illuminate the prospects of producing astaxanthin by microbial cell factories on industrial scale.