文献类型：期刊文献

英文题名：Peroxisome inspired hybrid enzyme nanogels for chemodynamic and photodynamic therapy

作者：Qin, Xing[1];Wu, Chu[2];Niu, Dechao[1];Qin, Limei[1];Wang, Xia[2];Wang, Qigang[2];Li, Yongsheng[1]

机构：[1]East China Univ Sci & Technol, Lab Low Dimens Mat Chem, Key Lab Ultrafine Mat, Sch Mat Sci & Engn,Minist Educ,Frontier Sci Ctr M, Shanghai, Peoples R China;[2]Tongji Univ, Sch Chem Sci & Engn, Shanghai, Peoples R China

年份：2021

卷号：12

期号：1

外文期刊名：NATURE COMMUNICATIONS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000695649500003)】；

基金：This work was financially supported by the National Key Research and Development Program of China (Grant No. 2016YFA0203700); The National Natural Science Foundation of China (Nos. 52072124, 51972112, 51773155, and 51873156); The National Natural Science Foundation of China for Innovative Research Groups (51621002); Natural Science Foundation of Shanghai (No. 20ZR1414900); Leading talents in Shanghai in 2018; Shanghai Municipal Science and Technology Major Project (2018SHZDZX03); The Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning and the 111 project (B14018).

语种：英文

摘要：Peroxisome, a special cytoplasmic organelle, possesses one or more kinds of oxidases for hydrogen peroxide (H2O2) production and catalase for H2O2 degradation, which serves as an intracellular H2O2 regulator to degrade toxic peroxides to water. Inspired by this biochemical pathway, we demonstrate the reactive oxygen species (ROS) induced tumor therapy by integrating lactate oxidase (LOx) and catalase (CAT) into Fe3O4 nanoparticle/indocyanine green (ICG) co-loaded hybrid nanogels (designated as FIGs-LC). Based on the O-2 redistribution and H2O2 activation by cascading LOx and CAT catalytic metabolic regulation, hydroxyl radical (center dot OH) and singlet oxygen (O-1(2)) production can be modulated for glutathione (GSH)-activated chemodynamic therapy (CDT) and NIR-triggered photodynamic therapy (PDT), by manipulating the ratio of LOx and CAT to catalyze endogenous lactate to produce H2O2 and further cascade decomposing H2O2 into O-2. The regulation reactions of FIGs-LC significantly elevate the intracellular ROS level and cause fatal damage to cancer cells inducing the effective inhibition of tumor growth. Such enzyme complex loaded hybrid nanogel present potential for biomedical ROS regulation, especially for the tumors with different redox state, size, and subcutaneous depth. The control of reactive oxygen species in cancer cells is an attractive approach for anticancer applications. Here, the authors create a peroxisome inspired lactate oxidase and catalase loaded hydrogel with iron nanoparticles and NIR photosensitizer for glutathione activated chemodynamic and photodynamic therapy.