文献类型：期刊文献

英文题名：Microenvironment-feedback regulated hydrogels as living wound healing materials

作者：Cheng, Yibo[1,2];Wang, Yanwen[3];Wang, Yunyi[2];Tan, Poh-Ching[3];Yu, Shiyun[1];Li, Chi[2];Li, Zi-Yuan[1];Li, Qing-Feng[3];Zhou, Shuang-Bai[3];Wang, Chen[2];Zhang, Junji[1];Tian, He[1]

机构：[1]East China Univ Sci & Technol, Inst Fine Chem, Sch Chem & Mol Engn, Shanghai, Peoples R China;[2]East China Normal Univ, Sch Chem & Mol Engn, Shanghai 200241, Peoples R China;[3]Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Dept Plast & Reconstruct Surg, Sch Med, Shanghai, Peoples R China

年份：2025

卷号：16

期号：1

外文期刊名：NATURE COMMUNICATIONS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001523451000030)】；

基金：This work is supported by Ministry of Science and Technology of China (2024YFB3814900, 2022YFA1505900,C.W.), NSFC (22202073 C.W., 22378121 J.J.Z., 22105070 Z.Y.L., 82272287 S.B.Z.), Natural Science Foundation of Chongqing (CSTB2023NSCQ-MSX0159, C.W.), Science and Technology Commission of Shanghai Municipality (24DX1400200, H.T.), the Fundamental Research Funds for the Central Universities (222201717003, H.T.), Cross disciplinary Research Fund of Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine (JYJC202215 S.B.Z.). J.J.Z. acknowledges Shanghai Natural Science Foundation Project (23ZR1479500, 23JC1401700).

语种：英文

摘要：Physiological microenvironments present a time-dependent variation during pathogenic or therapeutic processes, which call for life-like biomaterials of dynamic adaptation. However, current prevailed biomaterials maintain a passively responsive mode and lack autonomous and interactive dynamics. Striving for a paradigm of microenvironment interactive and self-regulatory medical agents as next-generation of biomaterials is of desperate need. Herein, we develop a microenvironment-feedback hydrogel as a living dressing biomaterial catering diabetic chronic wounds. This dynamic hydrogel leverages the initial alkaline pH of the wound bed as fuel and employs biocatalytic acid generation as the anti-fuel. By coupling this feedback loop to pH-regulated imine crosslinks, the hydrogel facilitates adaptive sol-gel cycling with programmable glucose oxidase (GOx) release in a Type-I diabetic mouse model. Thus, homeostatic wound pH and blood glucose levels are achieved, favoring accelerated in vivo wound healing and tissue repair.