文献类型：期刊文献

英文题名：Molecularly near-infrared fluorescent theranostics for in vivo tracking tumor-specific chemotherapy

作者：Yan, Chenxu[1,2];Shi, Limin[1,2];Guo, Zhiqian[1];Zhu, Weihong[1,2]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Inst Fine Chem,Key Lab Adv Mat, Feringa Nobel Prize Scientist Joint Res Ctr,Shang, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Chem & Mol Engn, Inst Fine Chem,Joint Int Res Lab Precis Chem & Mo, Feringa Nobel Prize Scientist Joint Res Ctr,Shang, Shanghai 200237, Peoples R China

年份：2019

卷号：30

期号：10

起止页码：1849

外文期刊名：CHINESE CHEMICAL LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000494893200019)】；

基金：This work was supported by the National Natural Science Foundation of China (Nos. 21788102, 21421004, 21636002, 21622602 and 21908060), National Key Research and Development Program (No. 2017YFC0906902), Shanghai Municipal Science and Technology Major Project (No. 2018SHZDZX03), the Innovation Program of Shanghai Municipal Education Commission, Scientific Committee of Shanghai (No. 15XD1501400), and China Postdoctoral Science Foundation (No. 2019M651417).

语种：英文

外文关键词：Near-infrared fluorescence; Fluorescent probe; Theranostic; Prodrug; Chemotherapy

摘要：Molecularly near-infrared (NIR) theranostics, combining in vivo sensing and tumor-specific therapeutic capability within one molecular system, have received considerable attention in recent years. Compared with the visible fluorescence imaging, NIR imaging (emission wavelength at 650-900 nm) possesses unique advantages including the minimum photodamage to biological samples, deep penetration, and low interference from auto-fluorescence. In over past decades, there has been an explosive development in the design of molecular imaging contrasts and imaging-guided therapeutics. In this review, we have sumarried the strategies of the NIR theranostics for imaging and tumor-specific chemotherapy applications in living systems. It is noted that the molecularly NIR theranostic design strategy could address current challenges of real-time in vivo sense-and-release for the intelligent biosensing and personalized treatment. (C) 2019 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.