文献类型：期刊文献

英文题名：A preliminary study on L-lysine fermentation from lignocellulose feedstock and techno-economic evaluation

作者：Chen, Zeyu[1];Liu, Gang[1];Zhang, Jian[1];Bao, Jie[1]

机构：[1]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China

年份：2019

卷号：271

起止页码：196

外文期刊名：BIORESOURCE TECHNOLOGY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000448161200025)】；

基金：This research was supported by Natural Science Foundation of China (21306048), and sponsored by Shanghai Pujiang Program.

语种：英文

外文关键词：L-Lysine; Corynebacterium glutamicum; Corn stover; Techno-economic analysis; Dry biorefinery processing; Minimum L-lysine selling price

摘要：L-Lysine is a commodity amino acid produced from starch feedstock. Various alternative feedstocks had been used for L-lysine production, but the yield was very low. This study took the first preliminary investigation on L-lysine production from lignocellulose for the replacement of food-crop starch. Corn stover was dry acid pre-treated and biodetoxified, then used for enzymatic hydrolysis and L-lysine fermentation by an industrial Corynebacterium glutamicum strain. Various fermentation parameters, nutrient additions, and operation variables were applied and finally 33.8 g/L of L-lysine was obtained. This L-lysine titer is still below that of starch based fermentation, but already 3-5 folds greater than that of other alternative feedstocks based fermentation. A techno-economic analysis was conducted and the minimum selling price of L-lysine (hydrochloride form) was calculated to be $2.445 per kg. The cost reduction by the future improvement could fill the technical and economic gap between the cellulosic and starch based L-lysine production.