文献类型：期刊文献

英文题名：A Polymeric Strategy Empowering Vascular Cell Selectivity and Potential Application Superior to Extracellular Matrix Peptides

作者：Zhou, Ruiyi[1];Wu, Yueming[2];Chen, Kang[2];Zhang, Deteng[3];Chen, Qi[2];Zhang, Donghui[1];She, Yunrui[2];Zhang, Wenjing[2];Liu, Longqiang[2];Zhu, Yueqi[4];Gao, Changyou[3];Liu, Runhui[1,2,5]

机构：[1]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Mat Sci & Engn, Res Ctr Biomed Mat,Minist Educ,Shanghai Frontiers, Key Lab Ultrafine Mat,Frontiers Sci Ctr Materiobi, Shanghai 200237, Peoples R China;[3]Zhejiang Univ, Dept Polymer Sci & Engn, MOE Key Lab Macromol Synth & Functionalizat, Hangzhou 310027, Peoples R China;[4]Shanghai Jiao Tong Univ Affiliated Peoples Hosp 6, Dept Radiol, 600 Yishan Rd, Shanghai 200233, Peoples R China;[5]Soochow Univ, State & Local Joint Engn Lab Novel Funct Polymer, Suzhou 215123, Peoples R China

年份：2022

卷号：34

期号：42

外文期刊名：ADVANCED MATERIALS

收录：;EI(收录号：20223912786483);WOS:【SCI-EXPANDED(收录号:WOS:000856164200001)】；

基金：This research was supported by the National Natural Science Foundation of China for Innovative Research Groups (No. 51621002), Program of Shanghai Academic/Technology Research Leader (20XD1421400), Key research and development program of Zhejiang Province (2022C01106), Shanghai Frontier Science Center of Optogenetic Techniques for Cell Metabolism (Shanghai Municipal Education Commission), Research program of State Key Laboratory of Bioreactor Engineering, the Fundamental Research Funds for the Central Universities (JKD01211520). China Postdoctoral Science Foundation (2021M701189). The authors also thank Research Center of Analysis and Test of East China University of Science and Technology for the help on the characterization. The authors thank the staff members of the Integrated Laser Microscopy System at the National Facility for Protein Science in Shanghai (NFPS), Zhangjiang Lab, China for providing technical support and assistance in data collection and analysis. All animal experiments in this study were approved by the Ethics Committee of Shanghai Jiao Tong University Affiliated Sixth People's Hospital and performed in accordance with the relevant guidelines and regulations.

语种：英文

外文关键词：EC-selective biomaterials; endothelialization; polymeric strategies; vascular stents; beta-peptide polymers

摘要：Endothelialization of vascular implants plays a vital role in maintaining the long-term vascular patency. In situ endothelialization and re-endothelialization is generally achieved by selectively promoting endothelial cell (EC) adhesion and, meanwhile, suppressing smooth muscle cell (SMC) adhesion. Currently, such EC versus SMC selectivity is achieved and extensively used in vascular-related biomaterials utilizing extracellular-matrix-derived EC-selective peptides, dominantly REDV and YIGSR. Nevertheless, the application of EC-selective peptides is limited due to their easy proteolysis, time-consuming synthesis, and expensiveness. To address these limitations, a polymeric strategy in designing and finding EC-selective biomaterials using amphiphilic beta-peptide polymers by tuning serum protein adsorption is reported. The optimal beta-peptide polymer displays EC versus SMC selectivity even superior to EC-selective REDV peptide regarding cell adhesion, proliferation, and migration of ECs versus SMCs. Study of the mechanism indicates that surface adsorption of bovine serum albumin, an abundant and anti-adhesive serum protein, plays a critical role in the ECs versus SMCs selectivity of beta-peptide polymer. In addition, surface modification of the optimal beta-peptide polymer effectively promotes the endothelialization of vascular implants and inhibits intimal hyperplasia. This study provides an alternative strategy in designing and finding EC-selective biomaterials, implying great potential in the vascular-related biomaterial study and application.