文献类型：期刊文献

英文题名：Aggregation Enhanced Responsiveness of Rationally Designed Probes to Hydrogen Sulfide for Targeted Cancer Imaging

作者：Wang, Rongchen[1,2];Gu, Xianfeng[3];Li, Qizhao[1,2];Gao, Jie[3];Shi, Ben[1,2];Xu, Ge[1,2];Zhu, Tianli[1,2];Tian, He[1,2];Zhao, Chunchang[1,2]

机构：[1]East China Univ Sci & Technol, Key Lab Adv Mat, Sch Chem & Mol Engn, Inst Fine Chem, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Feringa Nobel Prize Scientist Joint Res Ctr, Sch Chem & Mol Engn, Shanghai 200237, Peoples R China;[3]Fudan Univ, Sch Pharm, Dept Med Chem, Shanghai 201203, Peoples R China

年份：2020

卷号：142

期号：35

起止页码：15084

外文期刊名：JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

收录：;EI(收录号：20204109338719);WOS:【SCI-EXPANDED(收录号:WOS:000569271600026)】；

基金：We gratefully acknowledge financial support by the National Natural Science Foundation of China (21672062, 21874043, 21572039, and 21788102) and the Shanghai Municipal Science and Technology Major Project (Grant 2018SHZDZX03).

语种：英文

外文关键词：Sulfur compounds - Molecular imaging - Diseases

摘要：Activatable molecular probes hold great promise for targeted cancer imaging. However, the hydrophobic nature of most conventional probes makes them generate precipitated agglomerate in aqueous media, thereby annihilating their responsiveness to analytes and precluding their practical applications for bioimaging. This study reports the development of two small molecular probes with unprecedented aggregation enhanced responsiveness to H2S for in vivo imaging of H2S-rich cancers. The subtle modulation of the equilibrium between hydrophilicity and lipophilicity by N-methylpyridinium endows these designed probes with the capability of spontaneously self-assembling into nanoprobes under physiological conditions. Such probes in an aggregated state, rather than a molecular dissolved state, show NIR fluorescence light up and photoacoustic signals turn on upon H2S specific activation, allowing in vivo visualization and differentiation of cancers based on differences in H2S content. Thus, our study presents an effective design strategy which should pave the way to molecular design of optimized probes for precision cancer diagnostics.