文献类型：期刊文献

中文题名：Permissive role of CTCF–Hoxb7a–Cdkn2a/b axis in the emergence of hematopoietic stem and progenitor cells during zebrafish embryogenesis

作者：Wenjuan Zhang[1,2];Xiaofen Liu[2];Wenzhi Xue[2];Lei Gao[2];Dantong Li[2];Changbin Jing[2];Jian Zhao[1];Weijun Pan[1,2]

机构：[1]State Key Laboratory of Bioreactor Engineering,East China University of Science and Technology,Shanghai 200237,China;[2]CAS Key Laboratory of Nutrition,Metabolism and Food Safety,Shanghai Institute of Nutrition and Health(SINH),University of Chinese Academy of Sciences,Chinese Academy of Sciences,Shanghai 200031,China

年份：2024

卷号：51

期号：9

起止页码：974

中文期刊名：Journal of Genetics and Genomics

外文期刊名：遗传学报（英文版）

收录：CSTPCD;;Scopus;CSCD:【CSCD2023_2024】；PubMed;

基金：supported by the National Key R&D Program of China(2018YFA0800203);the National Natural Science Foundation of China(Distinguished Young Scholars 31925014,Key Program 32130033;General Program 31571505);the Key Research Program of Frontier Sciences,Chinese。

语种：英文

中文关键词：CTCF;eliminate;hematopoietic;

摘要：Hematopoietic stem and progenitor cells(HsPCs)are a subset population of multi-potent cells with self-renewal capability and differentiation into all lineages of blood cells(Zhang and Liu,2024).HSPCs arise from the ventral wall of embryonic dorsal aorta,the hemogenic endothelium in the aorta-gonad-mesonephros(AGM)region,tightly controlled by epigenetic,transcriptional,and signaling networks(Wu and Hirschi,2021).However,how developmental hemogenic endothelium performs cell fate surveillances during HSPC emergence and efficiently eliminates them to avoid abnormal hematopoiesisremainselusive.