文献类型：期刊文献

英文题名：Transition-metal-free access to benzyl ethers via aerobic cross-dehydrogenative coupling of benzylic C(sp3)-H bonds with alcohols

作者：Zhang, Xiao[1,2];Li, Wenjie[1,2];Yu, Yang[1,2];Luo, Min[1,2];Bai, Hua[1,2];Shi, Lei[3];Li, Hao[1,2]

机构：[1]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai Key Lab New Drug Design, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Pharm, 130 Meilong Rd, Shanghai 200237, Peoples R China;[3]Dohler Food & Beverage Ingredients Shanghai Co Ltd, 739 Shennan Rd, Shanghai 201108, Peoples R China

年份：2024

卷号：26

期号：4

起止页码：2207

外文期刊名：GREEN CHEMISTRY

收录：;EI(收录号：20240415426568);WOS:【SCI-EXPANDED(收录号:WOS:001144009000001)，CCR-EXPANDED(收录号:WOS:001144009000001)】；

基金：This work was supported by the Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning (GZ2017007) and the China 111 Project (Grant B07023).

语种：英文

外文关键词：Ethers - Molecular oxygen - Oxidants - Potassium hydroxide

摘要：We have developed a practical KOtBu- or KOH-catalyzed aerobic cross-dehydrogenative coupling of benzylic C(sp(3))-H bonds with various alcohols utilizing molecular oxygen as the sole oxidant. This transition-metal-free and chemical-oxidant-free methodology could enable direct and selective alkoxylation of benzylic C(sp(3))-H bonds, especially the primary benzylic C-H bond, which is prone to undergo overoxidation. Moreover, the aerobic oxidative C-H/O-H cross-coupling approach provides a practical and sustainable pathway to construct benzyl ethers with high chemoselectivity under mild reaction conditions.