文献类型：期刊文献

英文题名：Nanoscale covalent organic framework-mediated pyroelectrocatalytic activation of immunogenic cell death for potent immunotherapy

作者：Li, Xingguang[1];Gao, Meng-Lu[1];Wang, Shan-Shan[1];Hu, Yizhi[1];Hou, Dongzhi[1];Liu, Pei-Nian[1,2];Xiang, Huijing[3]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Shanghai Key Lab Funct Mat Chem, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[2]China Pharmaceut Univ, Sch Pharm, State Key Lab Nat Med, Nanjing 210009, Peoples R China;[3]Shanghai Univ, Sch Life Sci, Shanghai 200444, Peoples R China

年份：2024

卷号：10

期号：48

外文期刊名：SCIENCE ADVANCES

收录：;EI(收录号：20245017503274);WOS:【SCI-EXPANDED(收录号:WOS:001402032000010)】；

基金：This work was supported by National Natural Science Foundation of China (nos. 22201073, 21925201, 22161160319, T2322018, and 32171391), Shanghai Rising- Star Program (22QA1403600), and the Fundamental Research Funds for the Central Universities.

语种：英文

外文关键词：Cell death - Laser ablation - Reactive oxygen species

摘要：The conventional molecular immunogenic cell death (ICD) inducers suffer from poor biocompatibility and unsatisfactory efficacy. Here, a biocompatible nanosized covalent organic framework (nCOF)-based pyroelectric catalyst (denoted as TPAD-COF NPs) is designed for pyroelectric catalysis-activated in situ immunotherapy. TPAD-COF NPs confine organic pyroelectric molecules to rigid TPAD-COF NPs to substantially reduce aggregation and enhance biocompatibility, thus improving pyroelectrocatalytic efficiency. After tumor internalization, TPAD-COF NPs facilitate photothermal tumor ablation under near-infrared (NIR) laser exposure, resulting in effective ICD induction. In addition, TPAD-COF NPs effectively catalyze the conversion of temperature changes to pyroelectric changes, which subsequently react with adjacent O2 to generate reactive oxygen species, thus triggering robust ICD activation. In vivo evaluation using mouse models confirmed that TPAD-COF NPs evidently inhibited the proliferation of primary and distant tumors and prevented lung metastasis under NIR laser illumination. Therefore, this study opens an avenue for designing nCOF-based catalysts for pyroelectric catalysis-activated in situ immunotherapy.