文献类型：期刊文献

英文题名：Quick Serological Detection of a Cancer Biomarker with an Agglutinated Supramolecular Glycoprobe

作者：He, Xiao-Peng[1,2];Hu, Xi-Le[1,2];Jin, Hong-Ying[1,2];Gan, Jiemin[4];Zhu, Huili[4];Li, Jia[3];Long, Yi-Tao[1,2];Tiant, He[1,2]

机构：[1]E China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Inst Fine Chem, Shanghai 200237, Peoples R China;[3]Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Natl Ctr Drug Screening, Shanghai 201203, Peoples R China;[4]Fudan Univ, Huadong Hosp, Shanghai 200040, Peoples R China

年份：2015

卷号：87

期号：17

起止页码：9078

外文期刊名：ANALYTICAL CHEMISTRY

收录：;EI(收录号：20153701256740);WOS:【SCI-EXPANDED(收录号:WOS:000360773100066)】；

基金：We thank the 973 project (Grant 2013CB733700), the National Natural Science Foundation of China (Grant 21176076), the Key Project of Shanghai Science and Technology Commission (Grant 13NM1400900), and the Fundamental Research Funds for Central Universities (Grant 222201414010). Prof. Yi Zang and Yue Zhang are warmly thanked for help in the cellular experiments. Prof. Xiongwen Zhang is warmly thanked for the animal experiments.

语种：英文

外文关键词：Cancer cells - Body fluids - Diagnosis - Antigen-antibody reactions - Diseases - Gold nanoparticles - Supramolecular chemistry

摘要：While serology represents the forefront technique for cancer diagnosis, current clinical methods for the detection of serum biomarkers have flaws in terms of the need of complicated manipulations, long analytical time, and high cost. Here, we develop a supramolecular glycoprobe for the quick serological detection of a cancer biomarker. The probe formed by agglutination between self-assembled glyco-gold nanoparticles and a lectin shows subtle optical variations upon the competitive recognition of a glycoprotein biomarker secreted by cancer cells, tumor-bearing mice, as well as clinical cancer patients, with no response to a series of controls including the serum of hepatitis patients. This research provides an insight into the development of effective tools for serological diagnosis of cancer.