文献类型：期刊文献

英文题名：Pod-Like Supramicelles with Multicompartment Hydrophobic Cores Prepared by Self-Assembly of Modified Chitosan

作者：Wang, Yiming[1];Wang, Jie[1];Wang, Tongshuai[1];Xu, Yisheng[1];Shi, Lei[2];Wu, Yongtao[2];Li, Li[1];Guo, Xuhong[1]

机构：[1]E China Univ Sci & Technol, State Key Lab Chem Engn, Shanghai 200237, Peoples R China;[2]Firmenich Aromat China Co Ltd, Shanghai 201108, Peoples R China

年份：2016

卷号：8

期号：2

起止页码：151

外文期刊名：NANO-MICRO LETTERS

收录：;EI(收录号：20175204579806);WOS:【SCI-EXPANDED(收录号:WOS:000373051100006)】；

基金：We gratefully acknowledge NSFC Grants (51403062, 51273063 and 20774030), China Postdoctoral Science Foundation (2013M541485), 111 Project Grant (B08021), the Fundamental Research Funds for the Central Universities, the higher school specialized research fund for the doctoral program (20110074110003) and the Open Project of Engineering Research Center of Materials-Oriented Chemical Engineering of Xinjiang Bingtuan (2015BTRC001) for support of this work.

语种：英文

外文关键词：Chitosan; Graft copolymers; Amphiphiles; Self-assembly; Multicompartment supramicelles

摘要：In this paper, pod-like supramicelles with multicompartment hydrophobic cores were prepared by self-assembly of amphiphilic N-phthaloylchitosan-g-poly(N-vinylcaprolactam) (PHCS-g-PNVCL) in aqueous medium. The employed biocompatible amphiphilic polymer was synthesized by grafting the carboxyl terminated poly(N-vinylcaprolactam) (PNVCL-COOH) chains onto N-phthaloylchitosan (PHCS) backbone. H-1 NMR and FTIR results confirmed the molecular structure of the copolymers. The morphology of the supramicelles assembled by PHCS-g-PNVCL was revealed by means of TEM and polarized light microscope. In solution, the supramicelles were very stable as monitored by DLS and zeta potential measurements. Temperature and pH presented significant influences on the size and size distribution of the supramicelles. These supramicelles with multicompartment hydrophobic cores should be ideal biomimetic systems with promising applications in drug delivery.