文献类型：期刊文献

英文题名：A super-stretchable, self-healing and injectable supramolecular hydrogel constructed by a host-guest crosslinker

作者：Zhou, Yang[1];Zhang, Yuanhao[1];Dai, Zhaobo[1];Jiang, Fang[1];Tian, Jia[1];Zhang, Weian[1]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Shanghai Key Lab Funct Mat Chem, Meilong Rd 130, Shanghai 200237, Peoples R China

年份：2020

卷号：8

期号：12

起止页码：3359

外文期刊名：BIOMATERIALS SCIENCE

收录：;EI(收录号：20203809212105);WOS:【SCI-EXPANDED(收录号:WOS:000542957800008)】；

基金：This work was financially supported by the National Natural Science Foundation of China (21875063), and the Science and Technology Commission of Shanghai Municipality for the Shanghai International Cooperation Program (19440710600).

语种：英文

外文关键词：Supramolecular chemistry - Tissue engineering - Amides - Controlled drug delivery - Drug interactions - Self-healing materials - Targeted drug delivery - Hydrogels

摘要：Supramolecular hydrogels based on host-guest interactions have drawn considerable attention due to their unique properties and promising applications. However, it is still a great challenge to construct supramolecular hydrogels that simultaneously achieve mechanical strength, processability, and biocompatibility. Herein, we present a rational design of a "supramolecular crosslinker" approach to fabricate a new host-guest hydrogel with super-stretchability, self-healing, and injectable properties and excellent biocompatibility. The star-shaped supramolecular crosslinker is formed by the host-guest interactions between octa-cyclodextrin polyhedral oligomeric silsesquioxane (OCDPOSS) and acrylamide-modified adamantane (Ad-AAm). Supramolecular hydrogels can be briefly prepared by UV-initiated copolymerization of acrylamide and supramolecular crosslinkers. Supramolecular hydrogels present impressive mechanical properties due to rigid POSS as the core of the supramolecular crosslinker. Moreover, multivalent host-guest interactions improve the ductility, rapid self-healing and injectable ability of these hydrogels. Simultaneously, these supramolecular hydrogels possess good biocompatibility and can be utilized as carriers for the sustained release of hydrophobic drugs. Thus, such supramolecular hydrogels will have potential applications for tissue engineering and drug delivery systems.