文献类型：期刊文献

英文题名：Biomimetic mineralization of calcium carbonate mediated by a polypeptide-based copolymer

作者：Zhu, Wenjie[1];Lin, Jiaping[1];Cai, Chunhua[1];Lu, Yingqing[1]

机构：[1]E China Univ Sci & Technol, Sch Mat Sci & Engn, Shanghai Key Lab Adv Polymer Mat,Minist Educ, Key Lab Ultrafine Mat,State Key Lab Bioreactor En, Shanghai 200237, Peoples R China

年份：2013

卷号：1

期号：6

起止页码：841

外文期刊名：JOURNAL OF MATERIALS CHEMISTRY B

收录：;EI(收录号：20131816283150);WOS:【SCI-EXPANDED(收录号:WOS:000314800000015)】；

基金：This work was supported by National Natural Science Foundation of China (50925308, 21234002), Key Grant Project of Ministry of Education (313020) and National Basic Research Program of China (no. 2012CB933600). Support from project of Shanghai municipality (10GG15) is also appreciated.

语种：英文

外文关键词：Amino acids - Chains - Carbonation - Calcite - Self assembly - Biomimetics - Ring opening polymerization

摘要：A novel copolymer, beta-cyclodextrin-b-poly(L-glutamic acid) (beta-CD-b-PLGA), was synthesized by ring-opening polymerization and subsequent hydrolysis reaction. The beta-CD-b-PLGA copolymer possesses an oligosaccharide beta-CD segment and a polypeptide PLGA segment, with chemical structure resembling natural glycoprotein. The copolymers were applied in regulating the crystallization of calcium carbonate. The effects of the concentration of copolymers and calcium ions were systemically investigated. Various morphologies, including rhombohedra, rod, pseudo-dodecahedra and rosette-like structures, were obtained by adjusting the polymer and Ca2+ concentrations of the initial solution. Investigation of the pseudo-dodecahedra growth mechanism indicates that the copolymers mediate amorphous calcium carbonate formation initially, and then regulate the meso-scale self-assembly of CaCO3 subunits. The morphology variation is influenced by the binding of beta-CD-b-PLGA chains on specific crystal faces combined with the steric repulsive force of beta-CD-b-PLGA chains.