文献类型：期刊文献

英文题名：Preparation and characterization of bioactive and degradable composites containing ordered mesoporous calcium-magnesium silicate and poly(L-lactide)

作者：Ji, Jiajin[1];Dong, Xieping[2];Ma, Xuhui[3];Tang, Songchao[1];Wu, Zhaoying[1];Xia, Ji[1];Wang, Quanxiang[1];Wang, Yutao[1];Wei, Jie[1]

机构：[1]E China Univ Sci & Technol, Key Shanghai Key Lab Adv Polymer Mat, Shanghai 200237, Peoples R China;[2]Jiangxi Peoples Hosp, Dept Orthopaed Surg, Nanchang 330006, Peoples R China;[3]Polymer Sci Shenzhen New Mat Co Ltd, Shenzhen 518101, Peoples R China

年份：2014

卷号：317

起止页码：1090

外文期刊名：APPLIED SURFACE SCIENCE

收录：;EI(收录号：20144400142692);WOS:【SCI-EXPANDED(收录号:WOS:000344379900118)】；

基金：This study was supported by grants from the National Natural Science Foundation of China (No. 51173041, 81271705 and 31271031) and the National Science and Technology Support Plan Projects (No. 2012BAD32801), Nano special program of Science and Technology Development of Shanghai (No. 12nm0500400), and Special program of strategic emerging industries development of Shenzhen (No. CXZZ2012070355537097).

语种：英文

外文关键词：Mesoporous materials; Polymer; Degradability; Bioactivity; Cytocompatibility

摘要：Polylactide (PLA) and its copolymers have been widely used for bone tissue regeneration. In this study, a bioactive composite of ordered mesoporous calcium-magnesium silicate (m-CMS) and poly(L-lactide) (PLLA) was fabricated by melt blending method. The results indicated that the m-CMS particles were entrapped by polymer phase, and crystallinity of PLLA significantly decreased while the thermal stability of the m-CMS/PLLA composites was not obviously affected by addition of the m-CMS into PLLA. In addition, compared to PLLA, incorporation of the m-CMS into PLLA significantly improved the hydrophilicity, in vitro degradability and bioactivity (apatite-formation ability) of the m-CMS/PLLA composite, which were m-CMS content dependent. Moreover, it was found that incorporation of the m-CMS into PLLA could neutralize the acidic degradation by-products and thus compensated for the decrease of pH value. In cell culture experiments, the results showed that the composite enhanced attachment, proliferation and alkaline phosphatase activity (ALP) of MC3T3-E1 cells, which were m-CMS content dependent. The results indicated that the addition of bioactive materials to PLLA could result in a composite with improved properties of hydrophilicity, degradability, bioactivity and cytocompatibility. (C) 2014 Elsevier B.V. All rights reserved.