文献类型：期刊文献

英文题名：Hydroxyapatite nanoparticles as a controlled-release carrier of BMP-2: absorption and release kinetics in vitro

作者：Xie, Guangping[1];Sun, Jiao[1];Zhong, Gaoren[2];Liu, Changsheng[3];Wei, Jie[3]

机构：[1]Shanghai Jiao Tong Univ, Sch Med, Shanghai Biomat Res & Testing Ctr, Shanghai Peoples Hosp 9, Shanghai 200011, Peoples R China;[2]Fudan Univ, Sch Pharm, Shanghai 200037, Peoples R China;[3]E China Univ Sci & Technol, Sch Mat Sci & Engn, Shanghai 200237, Peoples R China

年份：2010

卷号：21

期号：6

起止页码：1875

外文期刊名：JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE

收录：;EI(收录号：20102813074048);WOS:【SCI-EXPANDED(收录号:WOS:000278525300012)】；

基金：This work was supported by grants from Natural Science Foundation of China (No. 30870680), Science and Technology Commission of Shanghai (No. 0752nm026) and Shanghai Leading Academic Discipline Project (No. S30206).

语种：英文

外文关键词：Targeted drug delivery - Bone - Hydroxyapatite - Suspensions (fluids) - Controlled drug delivery - Kinetics - Scaffolds (biology)

摘要：Recently, nanoparticles have been extensively developed as controlled-release carriers; however, there has been little research on hydroxyapatite nanoparticles (HANPs) and their potential applications. In this study, HANPs were investigated as a controlled-release carrier of bone morphogenetic protein-2 (BMP-2), the absorption and release kinetics of which were analyzed in vitro. Different concentrations of BMP-2 solution were used to evaluate the adsorptive properties of HANPs. It was observed that the amount of BMP-2 adsorbed onto HANPs could be as high as 70 mu g/mg and that adsorption rate was highly correlated with the concentration of BMP-2 solution used. After absorption, the suspension of HANPs absorbed BMP-2 (HANPs/BMP-2) was incubated at 37A degrees C for 15 days and the release kinetics of BMP-2 from HANPs/BMP-2 was determined daily. The release profile showed sustained release of BMP-2 over the period of the investigation. Collectively, these results suggest that HANPs has the potential to function as a carrier for drug delivery systems and as a scaffold material in bone tissue engineering.