文献类型：期刊文献

英文题名：Electro-Sorting Create Heterogeneity: Constructing A Multifunctional Janus Film with Integrated Compositional and Microstructural Gradients for Guided Bone Regeneration

作者：Lei, Miao[1];Liao, Haitao[1];Wang, Shijia[1];Zhou, Hang[1];Zhu, Jianwei[1];Wan, Haoran[1];Payne, Gregory F.[2,3];Liu, Changsheng[1];Qu, Xue[1,4]

机构：[1]East China Univ Sci & Technol, Frontiers Sci Ctr Materiobiol & Dynam Chem, Sch Mat Sci & Engn, Key Lab Ultrafine Mat,Minist Educ, Shanghai 200237, Peoples R China;[2]Inst Biosci & Biotechnol Res, 5118 A James Clark Hall, College Pk, MD 20742 USA;[3]Robert E Fischell Biomed Device Inst, 5118 A James Clark Hall, College Pk, MD 20742 USA;[4]East China Univ Sci & Technol, Shanghai Frontier Sci Res Base Optogenet Tech Cell, Shanghai 200237, Peoples R China

年份：2024

卷号：11

期号：12

外文期刊名：ADVANCED SCIENCE

收录：;EI(收录号：20240315399314);WOS:【SCI-EXPANDED(收录号:WOS:001143454200001)】；

基金：M.L. and H.L. contributed equally to this work. Support from the National Key Research and Development Program of China (2021YFB3800800), the National Natural Science Foundation of China (31922041, 32171341, 32301113), the 111 Project (B14018), the Science and Technology Innovation Project and Excellent Academic Leader Project of Shanghai Science and Technology Committee (21S31901500, 21XD1421100) and the National Postdoctoral Program for Innovative Talents (BX20230122), and the Shanghai Sailing Program (23YF1409700), and the Shanghai Postdoctoral Excellence Program (2022157) and the China Postdoctoral Science Foundation (2022M721136). G.F.P. acknowledge the support from the U.S. National Science Foundation (CBET-1932963) and the Betty and Gordon Moore Foundation (11395).

语种：英文

外文关键词：controlled-heterogeneity; electro-sorting; gradient composition; guided bone regeneration; janus porous structure

摘要：Biology remains the envy of flexible soft matter fabrication because it can satisfy multiple functional needs by organizing a small set of proteins and polysaccharides into hierarchical systems with controlled heterogeneity in composition and microstructure. Here, it is reported that controlled, mild electronic inputs (<10 V; <20 min) induce a homogeneous gelatin-chitosan mixture to undergo sorting and bottom-up self-assembly into a Janus film with compositional gradient (i.e., from chitosan-enriched layer to chitosan/gelatin-contained layer) and tunable dense-porous gradient microstructures (e.g., porosity, pore size, and ratio of dense to porous layers). This Janus film performs is shown multiple functions for guided bone regeneration: the integration of compositional and microstructural features confers flexible mechanics, asymmetric properties for interfacial wettability, molecular transport (directional growth factor release), and cellular responses (prevents fibroblast infiltration but promotes osteoblast growth and differentiation). Overall, this work demonstrates the versatility of electrofabrication for the customized manufacturing of functional gradient soft matter.