文献类型：期刊文献

英文题名：Copper-catalyzed enantioselective alkynylation of pyrazole-4,5-diones with terminal alkynes

作者：Lu, Jian[1];Luo, Ling-Shan[1];Sha, Feng[1];Li, Qiong[1];Wu, Xin-Yan[1]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Key Lab Adv Mat, Shanghai 200237, Peoples R China

年份：2019

卷号：55

期号：77

起止页码：11603

外文期刊名：CHEMICAL COMMUNICATIONS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000487669300022)，CCR-EXPANDED(收录号:WOS:000487669300022)】；

基金：We are grateful for the financial support from the Shanghai Pujiang Program (18PJD010), the Fundamental Research Funds for the Central Universities (222201814019), and the Natural Science Foundation of Shanghai (19ZR1412300).

语种：英文

摘要：A copper-catalyzed enantioselective alkynylation between terminal alkynes and pyrazole-4,5-diones has been developed. With 2.5 mol% CuI and 3 mol% chiral ligand L15, chiral propargylic alcohols bearing a pyrazolone motif were produced in 82-99% yield and up to 98% ee. Moreover, both enantiomers of the chiral propargylic alcohols were obtained with ligands L12 and L15, respectively.