文献类型：期刊文献

英文题名：Novel polyurethane immobilized with heparin

作者：Wang, Jun-Bin; Zhao, Yan-Chao; Gong, Fei-Rong; Rao, Ju; Cheng, Shu-Jun

机构：[1] Key Laboratory for Ultra fine Materials, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China

年份：2008

卷号：34

期号：5

起止页码：704

外文期刊名：Huadong Ligong Daxue Xuebao /Journal of East China University of Science and Technology

收录：EI(收录号：20084811740427)

语种：英文

摘要：Polyurethanes containing carboxyl group were synthesized by two-step solution polymerization. Heparin was immobilized on the PU surface via reacting between carboxyl group and the amino group in the heparin by covalent immobilization technology in heparin sodium citrate buffer at 4°C. The heparinized polyurethanes were investigated by FT-IR, water contact angle and antithrombin tests. Results show that the highest heparin content of PU surface is in heparin sodium citrate buffer (pH=5.0) for 96 h. The water connect angle is reduced from 61° to 44° after heparinization. Meanwhile, heparinization observably improves the blood anticoagulation of polyurethane.