文献类型：期刊文献

英文题名：Disulfide-Crosslinked mPEG-PLA-(LA)4 Nanomicelles for Taxane Delivery in Breast Cancer Therapy

作者：Xie, Yukun[1];Wang, Hao[1];Xiang, Lanlan[1];Shen, Yuchen[2];Yang, Yujie[1];Liu, Jiajie[1,3];Teng, Xin[1]

机构：[1]East China Univ Sci & Technol, Sch Mat Sci & Engn, Shanghai Key Lab Adv Polymer Mat, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]Univ New South Wales, Fac Biomed Engn, Sydney, NSW 2052, Australia;[3]East China Univ Sci & Technol, Int Elite Engn Sch, Shanghai 200237, Peoples R China

年份：2026

卷号：31

期号：13

外文期刊名：MOLECULES

收录：;Scopus(收录号：2-s2.0-105044514429);WOS:【SCI-EXPANDED(收录号:WOS:001817847000001)】；

基金：This research project was sponsored by Shanghai Natural Science Foundation (General Program) with grant number 25ZR1401086.

语种：英文

外文关键词：paclitaxel; docetaxel; cabazitaxel; nanomicelles; breast cancer; disulfide-crosslinked

摘要：Taxanes represent a crucial class of chemotherapeutic agents clinically employed for the treatment of various malignancies, including breast cancer. Three commonly utilized taxanes-paclitaxel (Taxol), docetaxel (Taxotere), and cabazitaxel-are substantially limited by inherent drawbacks such as poor aqueous solubility, rapid clearance, and non-specific distribution. To enhance their anti-tumor efficacy against breast cancer, an mPEG-PLA-(LA)4 nanomicelle carrier was designed and synthesized in this study for the loading of these three taxanes. These nanomicelles were designed to improve the aqueous compatibility and nanomicelle-mediated delivery of hydrophobic taxanes. In vivo animal experiments were conducted to evaluate the therapeutic effects of the three drug-loaded nanomicelles on subcutaneous human breast cancer MCF-7 xenografts in BALB/c nude mice. The results demonstrated that the injectable paclitaxel, docetaxel, and cabazitaxel micelles exhibited significant inhibitory effects on the MCF-7 xenograft tumors. These findings suggest that mPEG-PLA-(LA)4 DS nanomicelles may serve as a structurally defined and versatile carrier platform for hydrophobic taxane delivery.