文献类型：期刊文献

英文题名：An Efficient Strategy for Protecting Dihydroxyl Groups of Catechols

作者：Huang, Wei-Bin[1];Guo, Ying[1];Jiang, Jian-An[1];Pan, Xian-Dao[2,3];Liao, Dao-Hua[1];Ji, Ya-Fei[1]

机构：[1]E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China;[2]Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China;[3]Peking Union Med Coll, Beijing 100050, Peoples R China

年份：2013

卷号：24

期号：6

起止页码：741

外文期刊名：SYNLETT

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000317956600014)，CCR-EXPANDED(收录号:WOS:000317956600014)】；

基金：The authors thank the National Natural Science Foundation of China (Project No. 21176074) for financial supports.

语种：英文

外文关键词：catechols; protection; ortho-dihydroxyl; 1,3-dibromopropane; benzo[b]1,4-dioxepans; deprotection; aluminum chloride

摘要：A novel strategy for protecting dihydroxyl groups of catechols has been developed. Base-mediated cyclizations of catechols with 1,3-dibromopropane provided the corresponding benzo[b] 1,4-dioxepans, and herefrom the protecting group was easily cleaved by aluminum chloride. The preparation of the antibacterial and antifungal agent 4-(2-aminothiazol-4-yl) benzene-1,2-diol from catechol reliably verified its availability amenable to various harsh reaction conditions.