文献类型：期刊文献

英文题名：Cascade reaction of alkynols with 1-(2-aminophenyl)prop-2-ynols to form a fused 5,5,6-tricyclic system: formation of four bonds in a single reaction

作者：Mao, Xiao-Feng;Zhu, Xiao-Ping;Li, Deng-Yuan;Jiang, Liang-Liang;Liu, Pei-Nian[1]

机构：[1]East China Univ Sci & Technol, Shanghai Key Lab Funct Mat Chem, Key Lab Adv Mat, Meilong Rd 130, Shanghai 200237, Peoples R China; East China Univ Sci & Technol, Sch Chem & Mol Engn, Meilong Rd 130, Shanghai 200237, Peoples R China

年份：2017

卷号：53

期号：61

起止页码：8608

外文期刊名：CHEMICAL COMMUNICATIONS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000406371000026)，CCR-EXPANDED(收录号:WOS:000406371000026)】；

基金：This work was supported by the National Natural Science Foundation of China (Project no. 21372072, 21561162003 and 21672059), the Program for Eastern Scholar Distinguished Professor and the Fundamental Research Funds for the Central Universities.

语种：英文

摘要：A novel cascade reaction of internal alkynols with 1-(2-aminophenyl)prop-2-ynols has been developed to forma new N, O-containing fused 5,5,6-tricyclic skeleton. Mechanistic studies indicate that this reaction proceeds via alkynol cycloisomerization, intermolecular substitution with 1-(2-aminophenyl) prop-2-ynols, and intermolecular addition with alkynols and consequent cyclizations. In this way, two C-C bonds, one C-O bond and one C-N bond form to give a tricyclic skeleton in a single reaction.