文献类型：期刊文献

中文题名：A reversed phase/hydrophilic interaction/ion exchange mixed-mode stationary phase for liquid chromatography

英文题名：A reversed phase/hydrophilic interaction/ion exchange mixed-mode stationary phase for liquid chromatography

作者：Sainan Zhang[1];Feifang Zhang[1];Bingcheng Yang[1];Xinmiao Liang[1]

机构：[1]Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology

年份：2019

卷号：30

期号：2

起止页码：470

中文期刊名：Chinese Chemical Letters

外文期刊名：中国化学快报（英文版）

收录：CSTPCD;;Scopus;CSCD:【CSCD2019_2020】；

基金：financially supported by the National Natural Science Foundation of China(Nos. 21477037, 21322502);the Outstanding Young Talent Cultivation Fund of East China University of Science and Technology

语种：英文

中文关键词：Mixed-mode;Stationary;phase;Reversed;phase;liquid;chromatography;Hydrophilic;interaction;liquid;chromatography;Ion;exchange;Drug;molecules

外文关键词：Mixed-mode;Stationary phase;Reversed phase liquid chromatography;Hydrophilic interaction liquid;chromatography;Ion exchange;Drug molecules

摘要：A reversed phase (RP)/hydrophilic interaction (HILIC)/ion exchange (IEX) mixed tri-mode stationary phase (TMSP) has been prepared via a divergent synthesis scheme starting from propylamine on silica then by amine-epoxy reactions with 1,4-butanedioldiglycidyl ether and tertiary amines (N,Ndimethyldecylamine, DMDA). Its retention mechanism was found to follow RP/HILIC/IEX mixed-mode.The stop-flow test revealed that TMSP had good compatibility with 100% aqueous mobile phase. It demonstrated effective separation towards several kinds of compounds or drug molecules and their counterions within a single run.
A reversed phase (RP)/hydrophilic interaction (HILIC)/ion exchange (IEX) mixed tri-mode stationary phase (TMSP) has been prepared via a divergent synthesis scheme starting from propylamine on silica then by amine-epoxy reactions with 1,4-butanedioldiglycidyl ether and tertiary amines (N,Ndimethyldecylamine, DMDA). Its retention mechanism was found to follow RP/HILIC/IEX mixed-mode.The stop-flow test revealed that TMSP had good compatibility with 100% aqueous mobile phase. It demonstrated effective separation towards several kinds of compounds or drug molecules and their counterions within a single run.