文献类型：期刊文献

英文题名：Scandium Pentafluorobenzoate-Catalyzed Unexpected Cascade Reaction of 2-Aminobenzaldehydes with Primary Amines: A Process for the Preparation of Ring-Fused Aminals

作者：Mao, Dan;Tang, Jun;Wang, Wenbo;Wu, Shengying;Liu, Xin;Yu, Jianjun[1];Wang, Limin

机构：[1]E China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China; E China Univ Sci & Technol, Inst Fine Chem, Shanghai 200237, Peoples R China

年份：2013

卷号：78

期号：24

起止页码：12848

外文期刊名：JOURNAL OF ORGANIC CHEMISTRY

收录：;EI(收录号：20140117150241);WOS:【SCI-EXPANDED(收录号:WOS:000329077900058)，CCR-EXPANDED(收录号:WOS:000329077900058)】；

基金：This research was financially supported by the National Nature Science Foundation of China (21272069, 20672035) and the Fundamental Research Funds for the Central Universities and Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences.

语种：英文

外文关键词：Scandium - Scandium compounds

摘要：An unexpected cascade reaction of 2-aminobenzaldehydes with arylamines catalyzed by scandium pentafluorobenzoate [Sc(Pfb)(3)] was reported as a facile strategy for the efficient synthesis of a novel class of polycyclic ring-fused aminals N-substituted-6,7,11b,13-tetrahydro-6,12-[1,2]benzenoquinazolino[3,4-a]-quinazolin-13-amines 1. Under similar conditions, a series of the analogues of Troger's base, 13-substituted-5,6,11,12-tetrahydro-6,12-epiminodibenzo[b,f][1,5]diazocines 2 were obtained when the arylamines were replaced by methanamines. A possible mechanism for the formation of 1 and 2 was proposed.