文献类型：期刊文献

英文题名：Antifouling zwitterionic poly-?-peptides

作者：Zhang, Donghui[1];Cao, Chuntao[2];Chen, Qi[2];Liu, Jingjing[2];Liu, Hengjiang[3,4];Liu, Yu[5];Yuan, Yuan[2];Liu, Honglai[3,4];Lin, Haodong[6];Liu, Runhui[1,2]

机构：[1]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Frontiers Sci Ctr Materiobiol & Dynam Chem, Res Ctr Biomed Mat, Sch Mat Sci & Engn,Minist Educ,Key Lab Ultrafine M, Shanghai 200237, Peoples R China;[3]East China Univ Sci & Technol, Sch Chem, State Key Lab Chem Engn, Shanghai 200237, Peoples R China;[4]East China Univ Sci & Technol, Sch Chem, Shanghai 200237, Peoples R China;[5]Sun Yat sen Univ, Sch Chem Engn & Technol, Zhuhai 519082, Peoples R China;[6]Shanghai Jiao Tong Univ, Shanghai Gen Hosp, Dept Orthoped Surg, Sch Med, Shanghai 200080, Peoples R China

年份：2022

卷号：27

外文期刊名：APPLIED MATERIALS TODAY

收录：;EI(收录号：20222012111934);WOS:【SCI-EXPANDED(收录号:WOS:000807479800002)】；

基金：Acknowledgments This research was supported by the National Natural ScienceFoundation of China (No. 22075078, 21774031) , Shanghai Sailing Program (No. 22YF1410100) , Program of Shanghai Academic/Tech-nology Research Leader (20XD1421400) . We thank Research Center of Analysis and Test of East China University of Science and Technology for the help on the characterization.

语种：英文

外文关键词：Antifouling; Zwitterionic poly-?-peptides; Surfaces functionalization; Resist microbial adhesion

摘要：Zwitterionic polypeptides with homogenous alternating charges draw a great deal of attentions for their anti-fouling property and biocompatibility. Antifouling zwitterionic polypeptides are synthesized from alpha-amino acid in previous studies, but with application limitation due to their susceptibility to proteolysis. In this study, we report zwitterionic poly-beta-peptides as promising antifouling materials owning to their resistance to proteolysis and easy synthesis. We develop a series of poly-beta-peptides, DbaYKY-poly(beta-diaminobutyric acid-glutamic acid) (P beta Dab-E), bearing zwitterionic amino acid in the side chain, combining with a surface-grafting tripeptide motif at the end of the polymer for easily surface functionalization. The P beta Dab-E can be easily modified to surface to resist protein adsorption, cell adhesion and microbial adhesion to a great extent owning to its strong hydration ability. The convenient surface modification strategy and promising antifouling performance imply P beta Dab-E great potential for application in the biomedical filed.