文献类型：期刊文献

中文题名：Design,synthesis and bioassay of the emerging photo-responsive fungicides

作者：Wen Fu[1];Xinyue Hu[1];Qinglong Yuan[1];Zhiping Xu[1];Jiagao Cheng[1];Zhong Li[1,2];Xusheng Shao[1,2,3,4]

机构：[1]Shanghai Key Laboratory of Chemical Biology,School of Pharmacy,East China University of Science and Technology,Shanghai 200237,China;[2]State Key Laboratory of Bioreactor Engineering,East China University of Science and Technology,Shanghai 200237,China;[3]Shanghai Frontier Science Research Base of Optogenetic Techniques for Cell Metabolism,School of Pharmacy,East China University of Science and Technology,Shanghai 200237,China;[4]Engineering Research Center of Pharmaceutical Process Chemistry,Ministry of Education,School of Pharmacy,East China University of Science and Technology,Shanghai 200237,China

年份：2023

卷号：34

期号：8

起止页码：223

中文期刊名：Chinese Chemical Letters

外文期刊名：中国化学快报（英文版）

收录：CSTPCD;;Scopus;CSCD:【CSCD2023_2024】；PubMed;

基金：This work was financially supported by the Natural Science Foundation of China(Nos.21877039,32072441);National Key Research and Development Program of China(No.2018YFD0200100);Innovation Program of Shanghai Municipal Education Commission(No.2017-01-07-00-02-E00037).

语种：英文

中文关键词：Phenamacril;Controlled release;Photoremovable protecting groups;Spatiotemporal;Significant difference

摘要：Precise and spatiotemporal control over the pesticide remains to be a challenge.More efficient controlled release systems(CRSs)have been developed to support the precise delivery of active ingredients.Herein,we incorporated the photoremovable protecting groups(PRPGs)into phenamacril(PHE)and obtained two photo-responsive fungicides of NV-PHE and DEACM-PHE.The 4,5-dimethoxy-o-nitrobenzyl(NV)or 7-diethylaminocoumarin(DEACM)-caged PHE could release the active molecule PHE after irradiation of UV light and blue light,respectively.Optical properties and in-vitro/vivo fungicidal activities of NV-PHE and DEACM-PHE demonstrated the feasibility for light controlled release of PHE.DEACM-PHE could release 98%PHE by illumination of blue light.The irradiated DEACM-PHE could preserve the similar bioactivity of PHE,and significantly improve the in-vitro/vivo fungicidal activities compared to the non-irradiated DEACM-PHE.The optical controlled release of PHE from DEACM-PHE enabled the precise and spatiotemporal delivery of PHE,diversifying the development of CRSs for pesticide,and providing environmentfriendly agricultural applications with high pesticide efficiency.