文献类型：期刊文献

英文题名：Regioselective Metal-Free One-Pot Synthesis of Functionalized 2-Aminothiophene Derivatives

作者：Luo, Xiaoyan[1];Ge, Li-Shi;An, Xing-Lan;Jin, Jing-Hai;Wang, Yu;Sun, Pei-Pei;Deng, Wei-Ping

机构：[1]E China Univ Sci & Technol, Shanghai Key Lab Funct Mat Chem, Shanghai 200237, Peoples R China; E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China

年份：2015

卷号：80

期号：9

起止页码：4611

外文期刊名：JOURNAL OF ORGANIC CHEMISTRY

收录：;EI(收录号：20151900832904);WOS:【SCI-EXPANDED(收录号:WOS:000354004600039)，CCR-EXPANDED(收录号:WOS:000354004600039)】；

基金：This work was financially supported by the Fundamental Research Funds for the Central Universities, the Natural Science Foundation of China (No. 21172068), and Shanghai Committee of Science and Technology (No. 14431902500).

语种：英文

外文关键词：Cyclization - Regioselectivity - Condensation reactions

摘要：A facile metal-free synthesis of 2-aminothiophene derivatives by the reaction of 2-ynals with thioamides in alcohols has been developed. This transformation allows the assembly of 2-aminothienyl ether derivative via a well-designed aldol condensation/regioselective intramolecular cyclization/conjugate addition cascade reaction and provides a straightforward synthetic protocol for constructing 2-,3,5-trisubstituted 2-aminothiophenes.