文献类型：期刊文献

英文题名：Self-Limited Hyperbranching Polymerization of Di-N-Phenoxycarbonyl N-Substituted Diglycines

作者：Wang, Siqi[1];Shen, Tianlun[1];Hao, Kai[1];Tao, Xinfeng[2];Sun, Jihong[3];Ling, Jun[1]

机构：[1]Zhejiang Univ, Dept Polymer Sci & Engn, MOE Key Lab Macromol Synth & Functionalizat, Hangzhou 310058, Peoples R China;[2]East China Univ Sci & Technol, Sch Mat Sci & Engn, Shanghai Key Lab Adv Polymer Mat, Shanghai 200237, Peoples R China;[3]Zhejiang Univ, Sir Run Run Shaw Hosp, Sch Med, Dept Radiol, Hangzhou 310016, Peoples R China

年份：2023

卷号：224

期号：15

外文期刊名：MACROMOLECULAR CHEMISTRY AND PHYSICS

收录：;EI(收录号：20232514273762);WOS:【SCI-EXPANDED(收录号:WOS:001015521300001)】；

基金：All the animal experiments in this study were approved by the Animal Welfare and Ethics Review Board of Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University (number: SRRSH202102144). All animal experiments were performed in accordance with the guidelines of the Institutional Animal Care and Use Committee (IACUC) of Zhejiang University. Financial support by the National Natural Science Foundation of China (22271252, 21901073, and 21871232), the Key Research and Development Program of Zhejiang Province (2019C03014), and "Chenguang Program" (18CG32) by Shanghai Education Development Foundation and Shanghai Municipal Education Commission.

语种：英文

外文关键词：aggregation-induced emission; hyperbranched polypeptoids; MRI; N-phenoxycarbonyl & alpha;-amino acids; ring-opening polymerization

摘要：Hyperbranched poly(a-amino acid)s have caught great attention due to their excellent biocompatibility, biodegradability, and bioactivity. However, hyperbranched polypeptoids are rarely reported because of the challenge of synthesis. Herein, unique polymerizations of N,N'-diphenoxycarbonyl-N,N'-(1,4-phenylenebismethylene)-diglycine (di-NNPC, an A*B*-A*B*-type monomer) which uncommonly result in hyperbranched polypeptoids rather than gels after the complete consumption of di-NNPC are reported. The molecular weights of the hyperbranched polypeptoids are controlled by the degree of branching via tuning the initial concentrations of monomer and basic catalyst. N-Phenyloxycarbonyl glycine pendant groups plentifully remained on the polymer chains are used for Gd3+ complexation and post-modification, which makes the hyperbranched polypeptoids multifunctional single molecular micelles applicable as magnetic resonance imaging contrast agents and photoluminescence probes.