文献类型：期刊文献

英文题名：Engineered Organosilica Hybrid Micelles for Photothermal-enhanced Starvation Cancer Therapy

作者：Li, Xianglong[1];Wu, Huan[1];Jiang, Cong[2];Zou, Jinglin[1];Wang, Qinghua[1];Guan, Mengjia[1];Hao, Ji-Na[1];Cao, Yuanyuan[1];Li, Yongsheng[1,3]

机构：[1]East China Univ Sci & Technol, Frontier Sci Ctr Mat Biol & Dynam Chem, Shanghai Engn Res Ctr Hierarch Nanomat,Minist Edu, Sch Mat Sci & Engn,Lab Low Dimens Mat Chem,Key La, Shanghai 200237, Peoples R China;[2]Tongji Univ, Shanghai Pulm Hosp, Dept Thorac Surg, Sch Med, Shanghai 200092, Peoples R China;[3]Shihezi Univ, Sch Chem & Chem Engn, Key Lab Green Proc Chem Engn Xinjiang Bingtuan, Shihezi 832003, Peoples R China

年份：2022

卷号：17

期号：17

外文期刊名：CHEMISTRY-AN ASIAN JOURNAL

收录：;EI(收录号：20222912365470);WOS:【SCI-EXPANDED(收录号:WOS:000848516100006)】；

基金：This work was financially supported by the National Natural Science Foundation of China (No. 51621002, 51972112, 52172279, 21805087), Shanghai Municipal Science and Technology Major Project (grant No. 2018SHZDZX03), Basic Research Program of Shanghai (21JC1406003 and 19JC1411700), Leading Talents in Shanghai in 2018, Shanghai Rising Star Program (21QA1402200), the Natural Science Foundation of Shanghai (21ZR1416600), the 111 project (B14018). The authors would like thank to the schematic diagram help by Figdraw (www.figdraw.com).

语种：英文

外文关键词：organosilica hybrid micelles; glucose oxidase; starvation therapy; photothermal effect

摘要：Glucose oxidase (GOD)-based starvation therapy (ST), which inhibits the growth and proliferation of cancer cells by consuming glucose, has attracted intensive attention as an emerging non-invasive method for fighting cancers. However, the enzyme activity of GOD is greatly limited in vivo because of its optimal catalytic activity in the temperature range of 43-60 degrees C. Herein, a photothermal-enhanced starvation strategy is developed based on our engineered organosilica hybrid micelles (TiO2-x@POMs-GOD), in which the fluoride-doped TiO2-x with photothermal properties is encapsulated in the cores of organosilica cross-linked micelles and GOD is immobilized on the carboxyl groups of PAA segments. With its internalization by cancer cells, the conjugated GOD can effectively deplete glucose to achieve the ST effect, which can be remarkably enhanced by the loaded fluoride-doped TiO2-x with NIR laser irradiation, thus cooperatively contributing to the efficient treatment of TiO2-x@POMs-GOD on various cancer cells. This suggests great potential for TiO2-x@POMs-GOD in photothermal-enhanced ST in vivo.