文献类型：期刊文献

英文题名：A new macrocyclic lactone and a new quinoflavan from Celastrus hindsii

作者：Hu, Xian-Qing[1];Han, Wei[1];Han, Zhu-Zhen[2];Liu, Qing-Xin[2];Xu, Xi-Ke[2];Fu, Peng[2];Li, Hui-Liang[2]

机构：[1]E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China;[2]Second Mil Med Univ, Sch Pharm, Dept Phytochem, Shanghai 200433, Peoples R China

年份：2014

卷号：7

起止页码：169

外文期刊名：PHYTOCHEMISTRY LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000330578100035)】；

基金：The work was supported by program NCET Foundation, NSFC (81230090, 81102335), partially supported by Global Research Network for Medicinal Plants (GRNMP) and King Saud University, Shanghai Leading Academic Discipline Project (B906), FP7-PEOPLE-IRSES-2008 (TCMCANCER Project 230232), Key Laboratory of Drug Research For Special Environments, PLA, Shanghai Engineering Research Center for the Preparation of Bioactive Natural Products (10DZ2251300) and the Scientific Foundation of Shanghai China (12401900801, 09DZ1975700, 09DZ1971500, 10DZ1971700, 11QA1408200), National Major Project of China (2011ZX09307-002-03), National Key Technology R&D Program of China (2012BAI29B06).

语种：英文

外文关键词：Celastrus hindsii; Macrocyclic lactones; Quinoflavans; Cytotoxicity

摘要：A new macrocyclic lactone named Hindsiilactone A (1), a new 5,8-quinoflavan named Hindsiiquinoflavan B (5), and three known compounds (Combretastatin D-2 (2), Combretastatin D-3 (3) and isocorniculatolide A (4)) were isolated from the 80% ethanol extract of the stems of Celastrus hindsii (Celastraceae). The structures were identified by UV, IR, HRESIMS, 1D and 2D NMR experiments, and the data were compared with the literature. The configuration of 1 was determined using X-ray crystallography for the first time. All of the isolated compounds were evaluated for cytotoxicity against four human tumor cell lines: NCI-H187, HCT116, BC-1 and HuH7. (C) 2013 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.