文献类型：期刊文献

英文题名：Confined Nanopipette Sensing: From Single Molecules, Single Nanoparticles, to Single Cells

作者：Yu, Ru-Jia[1];Ying, Yi-Lun[1];Gao, Rui[1];Long, Yi-Tao[1]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Key Lab Adv Mat, Shanghai 200237, Peoples R China

年份：2019

卷号：58

期号：12

起止页码：3706

外文期刊名：ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

收录：;EI(收录号：20185106276959);WOS:【SCI-EXPANDED(收录号:WOS:000462680700005)】；

基金：This research was supported by the National Natural Science Foundation of China (21834001, 61871183), Innovation Program of Shanghai Municipal Education Commission (2017-01-07-00-02-E00023), the "Chen Guang" project supported by Shanghai Municipal Education Commission and Shanghai Education Development Foundation (17CG27), and the Fundamental Research Funds for the Central Universities (222201718001, 222201717003, and 222201714012).

语种：英文

外文关键词：confined space; nanopipettes; nanopores; single-cell analysis; single-molecule sensing

摘要：Nanopipettes provide a promising confined space that enables advances in electrochemical, optical, and mass spectrometric measurements at the nanoscale. They have been employed to reveal the hidden population properties and dynamics of single molecules and single particles. Moreover, new detection mechanisms based on nanopipettes have led to detailed information on single cells at high spatial and temporal resolution. In this Minireview, we focus on the fabrication and characterization of nanopipettes, summarize their wide applications for the analysis of single entities, and conclude with an outlook for advanced practical sensing.