文献类型：期刊文献

英文题名：Luminescent metal-organic framework sensor for detection of biomarker 2-thiothiazolidine-4-carboxylic acid

作者：Ge, Kaiming[1];Hao, Ji-Na[1];Li, Yongsheng[1,2]

机构：[1]East China Univ Sci & Technol, Frontier Sci Ctr Mat Biol & Dynam Chem, Shanghai Engn Res Ctr Hierarch Nanomat,Minist Educ, Sch Mat Sci & Engn,Lab Low Dimens Mat Chem,Key Lab, Shanghai 200237, Peoples R China;[2]Shihezi Univ, Sch Chem & Chem Engn, State Key Lab Incubat Base Green Proc Chem Engn, Shihezi 832003, Peoples R China

年份：2024

卷号：52

期号：5

外文期刊名：CHINESE JOURNAL OF ANALYTICAL CHEMISTRY

收录：;EI(收录号：20241715987615);WOS:【SCI-EXPANDED(收录号:WOS:001234867200001)】；

基金：The authors are grateful for the financial support from the National Key Research and Development Program of China (2022YFC2403203), the National Natural Science Foundation of China (52172279), the Basic Research Program of Shanghai (21JC1406003), the Shanghai Rising Star Program (21QA1402200), the Natural Science Foundation of Shanghai (21ZR1416600), Leading Talents in Shanghai in 2018.r the National Natural Science Foundation of China (52172279) , the Basic Research Program of Shanghai (21JC1406003) , the Shanghai Rising Star Program (21QA1402200) , the Natural Science Foundation of Shanghai (21ZR1416600) , Leading Talents in Shanghai in 2018.

语种：英文

外文关键词：Optical biosensor; Lanthanide metal-organic framework; Biomarker; 2-thiothiazolidine-4-carboxylic acid

摘要：Using terephthalic acid (BDC) as the organic ligand and zirconium chloride (ZrCl4) as the metal source, a lanthanide metal-organic framework (Tb/Zr-UiO-66) with excellent luminescence properties was successfully prepared by introducing the lanthanide ion Tb3+ in situ through a simple one-pot hydrothermal reaction, which was designed as an optical biosensor for 2-thiothiazolidine-4-carboxylic acid (TTCA), the urinary biomarker of human exposure to carbon disulfide (CS2). The fabricated Tb/Zr-UiO-66 exhibits high chemical and luminescent stability, making it competent for recognizing TTCA in aqueous environments. Significantly, its luminescence intensity change shows a good linearity relationship with the concentration of TTCA in the range of 0-110 mu M, with a limit of detection (LOD) as low as 0.14 mu M. Meanwhile, this sensor exhibits good selectivity and anti-interference ability towards TTCA among the various coexisting components in urine (Na+, K+, NH4+, SO42-, Cl-, creatine, creatinine, glucose, urea, etc.), and can quickly respond to TTCA within 2 min. The analysis results of powder X-ray diffraction (PXRD), fluorescence lifetime and ultraviolet-visible (UV-vis) spectrum demonstrate that the sensing mechanism can be ascribed to the competition absorption effect between TCAA and Tb/Zr-UiO-66. This biosensor with simple synthesis, stable framework, high sensitivity and selectivity, and rapid response has potential to become a powerful tool for diagnosing diseases associated with CS2 exposure.