文献类型：期刊文献

中文题名：N-苯基八元氧桥环新烟碱化合物的合成及其增效活性

英文题名：Synthesis and synergistic activity of N-phenyl-eight-membered oxabridged neonicotinoid analogues

作者：Tan, Du[1]; Xu, Zhiping[1]; Shao, Xusheng[1]; Li, Zhong[1]

机构：[1] Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China

年份：2024

卷号：26

期号：1

起止页码：44

外文期刊名：Chinese Journal of Pesticide Science

收录：EI(收录号：20251918367852)

语种：中文

摘要：Insecticide synergists are key components to improve insecticidal efficacy and reduce resistance. In this work, further derivation of the eight-membered oxabridged structure with specific synergistic effect was conducted, fifteen novel N-phenyl-eight-membered oxabridged neonicotinoid derivatives were designed and synthesized, the mortality of the target compounds combined with imidacloprid against Aphis craccivora was tested. The results indicated that most of the target compounds increased the toxicity of imidacloprid against A. craccivora at the concentration of 1 mg/L. The non-substituted compound 4a and 4-CF3-substituted compound 4m exhibited the comparable synergistic effect, the synergism ratio was 3.44 and 3.58, respectively, which could be regarded as candidate compounds for further study. ? 2024 Editorial Office of Chinese Journal of Pesticide Science. All rights reserved.