文献类型：期刊文献

英文题名：Endogenous electric field-driven neuro-immuno-regulatory scaffold for effective diabetic wound healing

作者：Liu, Zhiqing[1];Wang, Tianlong[1];Zhao, Jinhui[1];Zhang, Lei[1];Luo, Yiping[1];Chen, Yixing[1];Wu, Xinhui[1];Liu, Yaqi[1];Aierken, Aihemaitijiang[1];Duolikun, Dilixiati[1];Jiang, Hui[1];Zhao, Xinyu[1];Li, Chang[1];Li, Yingchuan[5];Cao, Wentao[4];Du, Jianzhong[1,6,7];Zheng, Longpo[1,2,3]

机构：[1]Tongji Univ, Shanghai Peoples Hosp 10, Sch Med, Dept Orthoped, Shanghai 200072, Peoples R China;[2]Shanghai Trauma Emergency Ctr, Shanghai 200072, Peoples R China;[3]Tongji Univ, Shanghai Peoples Hosp 10, Orthoped Intelligent Minimally Invas Diag & Treatm, Sch Med, Shanghai 200072, Peoples R China;[4]Fudan Univ, Shanghai Stomatol Hosp & Sch Stomatol, Dept Prosthodont, Shanghai 201102, Peoples R China;[5]Tongji Univ, Shanghai Peoples Hosp 10, Sch Med, Dept Crit Care Med, Shanghai, Peoples R China;[6]Tongji Univ, Sch Mat Sci & Engn, Dept Polymer Mat, 4800 Caoan Rd, Shanghai 201804, Peoples R China;[7]East China Univ Sci & Technol, Sch Mat Sci & Engn, Shanghai 200237, Peoples R China

年份：2025

卷号：47

起止页码：266

外文期刊名：BIOACTIVE MATERIALS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001426919500001)】；

基金：Zhiqing Liu, Tianlong Wang, Jinhui Zhao, and Lei Zhang contributed equally to this work. This work was financially supported by National Key R &D Program of China (Grant No. 2024YFC2420200, and 2022YFC2402900), the National Natural Science Foundation of China (Grant No. 82372395, 52202108, 22335005, and 21925505), the Special Project for Promoting High-Quality Development of Industries of Shanghai Municipal Commission of Economy and Informatization (Project No. 2023-GZL-RGZN-01037), Shanghai Science and Technology Innovation Action Plan (Grant No. 23S31905700), Natural Science Foundation of Shanghai Municipality (Grant No. 21ZR1450000), and Innovation Program of Shanghai Municipal Education Commission (2023ZKZD28).

语种：英文

外文关键词：Conductive scaffold; Wound exudate management; Endogenous electric field; Neuro-immuno-regulatory; Diabetic wound healing

摘要：The pathological microenvironment in diabetic wounds is delineated by heightened inflammatory responses and persistent proinflammatory macrophage activity, which significantly hinders the wound healing process. Exogenous electrical stimulation (ES), by modulating the electric field distribution in wounds, has shown significant potential in treating inflammatory wounds. However, this approach relies on additional power sources and complex circuit designs. Here, a bionic neuro-immuno-regulatory (BNIR) system was proposed for reshaping the endogenous electric fields (EFs) through collecting ion flow. The BNIR system comprises microporous structure scaffolds and nanosheets, enabling swift biofluid collection and electrical signal transmission, with the ability to promote cell proliferation and migration and exhibit antioxidant properties. More importantly, the BNIR system induced the transition of M1 macrophages to M2 macrophages through neuro-immuno-regulatory. In diabetic rat skin wounds, the BNIR system significantly enhanced healing by simultaneously neuro-immunoregulatory, promoting angiogenesis, scavenging ROS, and facilitating tissue remodeling. This work aims to advance the development of a bionic system for electrosensitive tissue repair.