文献类型：期刊文献

英文题名：Fabrication of uniform, biocompatible and multifunctional PCL-b-PAA copolymer-based hybrid micelles for magnetic resonance imaging

作者：Niu, Dechao[1]; Liu, Xiaohang[2]; Li, Yongsheng[1]; Ma, Zhi[3]; Dong, Wenjie[1]; Chang, Shu[1]; Zhao, Wenru[1]; Gu, Jinlou[1]; Zhang, Shengjian[2]; Shi, Jianlin[1,4]

机构：[1] Key Laboratory for Ultrafine Materials, East China University of Science and Technology, Ministry of Education, Shanghai 200237, China; [2] Department of Radiology, Shanghai Cancer Hospital, Fudan University, Shanghai 200032, China; [3] Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China; [4] State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China

年份：2011

卷号：21

期号：36

起止页码：13825

外文期刊名：Journal of Materials Chemistry

收录：EI(收录号：20113614306223)

语种：英文

外文关键词：Magnetic resonance imaging - Fluorescence imaging - Silica - Biocompatibility - Micelles - Self assembly - Polyethylene glycols - Polyethylene oxides - Fabrication - Magnetite nanoparticles

摘要：In this paper, a simple strategy was developed to fabricate a novel kind of uniform, biocompatible and PEGylated multifunctional hybrid micelles with multiple magnetite nanocrystal loaded cores and dye-doped silica cross-linked shells based on the self-assembly between poly(Ε-caprolactone)-b- poly(acrylic acid) copolymer and inorganic nanoparticles. The loading of multiple magnetite nanoparticles in the core part of the hybrid micelles endows them with T2-weighted MR imaging functionalities. Small dye molecules (Rhodamine B) were directly incorporated into the silica layer framework during the cross-linking process, imparting the hybrid micelles with fluorescent imaging modality. Poly(ethylene glycol) (PEG) was grafted to reduce the phagocytic capture of nanoparticles by cellular components of the immune system. Importantly, the potential application of magnetite incorporated PEGylated hybrid micelles as T2 contrast agents for MRI was demonstrated both in vitro and in vivo, with the passive targeting behavior via EPR effect due to the leaky vasculature and poor lymphatic drainage in tumors. ? 2011 The Royal Society of Chemistry.