文献类型：期刊文献

中文题名：头朝向细胞三维空间活动模式的神经动力学建模

英文题名：Neurodynamical Modeling of 3D Spatial Activity Patterns of Head-Direction Cells

作者：许霜[1];王毅泓[1];徐旭颖[1];潘晓川[1];王如彬[1]

机构：[1]华东理工大学数学学院,上海200237

年份：2025

卷号：46

期号：7

起止页码：836

中文期刊名：应用数学和力学

外文期刊名：Applied Mathematics and Mechanics

收录：;北大核心:【北大核心2023】；

基金：国家自然科学基金(12172132,12272136,12472054)。

语种：中文

中文关键词：空间导航;神经动力学;头朝向细胞;连续吸引子网络;三维空间

外文关键词：spatial navigation;neurodynamics;head-direction cell;continuous attractor network;3D space

摘要：哺乳动物的内嗅皮层等多个脑区中存在头朝向细胞(head-directioncells,HDcells),对特定的头部朝向进行选择性响应,构成了大脑内部的指南针系统.该系统可以以自组织的方式更新内部方向表征,也可以接收外部环境信息输入,对方向编码进行校准.目前,大多数头朝向细胞的计算模型只考虑了水平面上的头部方向编码.而实验表明,哺乳动物(例如蝙蝠)脑内存在同时编码水平方位角和竖直俯仰角的神经元,但目前还缺乏对其神经机制的计算建模研究.对此,本研究构造了一个能够同时编码方位角和俯仰角等三维方向特征的连续吸引子网络模型,不仅在单神经元水平上实现了三维头朝向细胞特定的方向偏好编码,而且在群体水平上实现了对三维空间中头部方向变化的准确追踪.模型使用的环面拓扑连接结构,相对于球面拓扑能更合理地解释蝙蝠记录的神经元对方位角的调谐数据.本研究通过神经动力学模型重现了电生理实验记录到的三维头朝向编码的现象,并对头朝向细胞三维空间的活动模式给出了动力学角度的机理解释.
Head-direction cells are present in several brain regions,including the mammalian medial entorhinal cortex,and respond selectively to specific head directions,and constitute a compass system in the brain.This system can update internal direction representations in a self-organized manner,and can receive inputs from the external environment to calibrate direction encoding.Currently,many computational models for head-direction cells only consider head directions encoding in the horizontal plane.Whereas experiments show that neurons encoding both horizontal azimuth and vertical pitch angles exist in the brains of mammals,there is a lack of computational modeling of their neural mechanisms.A continuous attractor network model was constructed to encode 3D direction features such as azimuth and pitch angles at the same time,realizing both the specific direction preference encoding of 3D-head-direction cells at the single-neuron level and the accurate tracking of head direction changes in 3D space at the population level.The torus topology used in the model,compared with the spherical topology,can more reasonably explain the neuronal tuning data for azimuth recorded by bats.The proposed neurodynamic model reproduces the phenomena encoded by electrophysiological experiments recorded in 3D head directions and gives a mechanistic explanation of the dynamical angles of the activity patterns of head-direction cells in the 3D space.