文献类型：期刊文献

英文题名：Catalytic Reductive Addition of Imine for Chiral Amine Synthesis: Recent Advances and Future Perspectives

作者：Xia, Tingting[1,2];Yu, Zhiying[1,2];Wu, Xianqing[1,2];Qu, Jingping[1,2];Chen, Yifeng[1,2,3,4]

机构：[1]East China Univ Sci & Technol, Key Lab Adv Mat, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Feringa Nobel Prize Scientist Joint Res Ctr, Frontiers Sci Ctr Materiobiol & Dynam Chem, Sch Chem & Mol Engn,Joint Int Res Lab Precis Chem, 130 Meilong Rd, Shanghai 200237, Peoples R China;[3]Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China;[4]Henan Normal Univ, Sch Chem & Chem Engn, Xinxiang 453007, Peoples R China

年份：2025

卷号：17

期号：1

外文期刊名：CHEMCATCHEM

收录：;EI(收录号：20250217666786);WOS:【SCI-EXPANDED(收录号:WOS:001374685000001)】；

基金：This work was supported by the National Natural Science Foundation of China (22171079, 22371071, 92356301), Shanghai Municipal Science and Technology Major Project (Grant No.2018SHZDZX03), the Program of Introducing Talents of Discipline to Universities (B16017), Shanghai Sailing Program (23YF1408800), and the Fundamental Research Funds for the Central Universities.

语种：英文

外文关键词：Asymmetric catalysis; Chiral amine; Imine; Reductive addition

摘要：Optically active amine represents the most important structure motif in natural products and biologically active compounds. Stereoselective reductive addition of imine with the utilization of electrophilic component offers a concise and operationally simple method for the synthesis of chiral amines. This review mainly highlights recent significant synthetic methodology developments in reductive addition of imine for chiral amine synthesis including chiral auxiliary-mediated diastereoselective transformation, asymmetric transition metal catalysis, organocatalysis, and enzymatic catalysis. In addition, the electrophilic reagents scopes and mechanistic aspects have also been introduced in this review.