文献类型：期刊文献

英文题名：Self-Assembly of a Mixture System Containing Polypeptide Graft and Block Copolymers: Experimental Studies and Self-Consistent Field Theory Simulations

作者：Zhuang, Zeliang[1];Zhu, Xiaomeng[1];Cai, Chunhua[1];Lin, Jiaping[1];Wang, Liquan[1]

机构：[1]E China Univ Sci & Technol, Sch Mat Sci & Engn, Minist Educ,Shanghai Key Lab Adv Polymer Mat, Key Lab Ultrafine Mat,State Key Lab Bioreactor En, Shanghai 200237, Peoples R China

年份：2012

卷号：116

期号：33

起止页码：10125

外文期刊名：JOURNAL OF PHYSICAL CHEMISTRY B

收录：;EI(收录号：20133616698071);WOS:【SCI-EXPANDED(收录号:WOS:000307749100027)】；

基金：This work was supported by the National Natural Science Foundation of China (50925308), the Program for Changjiang Scholars and Innovative Research Team in University (No. IR T0825), and the National Basic Research Program of China (No. 2012CB933602). Support from projects of the Shanghai municipality (10GG115 and 08DZ2230500) is also appreciated.

语种：英文

外文关键词：Solutions - Aggregates - Graft copolymers - Mean field theory - Micelles - Grafting (chemical) - Polyethylene glycols - Self assembly - Molecular orbitals - Polyethylene oxides

摘要：Self-assembly behavior of mixture systems containing poly(gamma-benzyl-L-glutamate)-poly(ethylene glycol) graft (PBLG-g-PEG) and block (PBLG-b-PEG) copolymers in aqueous solution was investigated by both experiments and computer simulations. Pure graft copolymers self-assembled into vesicles, and pure block copolymers aggregated into spherical micelles or vesicles, while, for the mixture systems, hybrid cylindrical micelles were observed In addition to the experimental observations, self-consistent field theory (SCFT) simulations were performed on the self-assembly behavior of graft/block copolymer mixtures. Simulation results reproduced the morphological transitions observed in the experiments. Moreover, from the SCFT simulations, the chain distributions of copolymers in the aggregates were obtained. For the hybrid cylindrical micelles, block copolymers were found to mainly locate at the ends of aggregates, which prevents the fusion of cylinders to vesicles. By combining experimental findings with simulation results, the mechanism regarding the morphological transition of the aggregates formed by graft/block copolymer mixtures is proposed.