文献类型：期刊文献

英文题名：Computational Modeling With Phantom-Tissue Validation of Gold-Nanorod-Enhanced Laser Ablation of Prostate Cancer

作者：Liang, Huishan[1];Qian, Zhiqin[1];Zhang, Hanwei[1];Luo, Yigang[2];Moser, Michael A. J.[2];Zhang, Wenjun[3];Zhang, Bing[4]

机构：[1]East China Univ Sci & Technol, Sch Mech & Power Engn, Shanghai 200237, Peoples R China;[2]Univ Saskatchewan, Dept Surg, Saskatoon, SK S7N 5E5, Canada;[3]Univ Saskatchewan, Dept Mech Engn, Saskatoon, SK S7N 5A9, Canada;[4]Shanghai Univ, Sch Mechatron Engn & Automat, Intelligent Energy Based Tumor Ablat Lab, Shanghai 222444, Peoples R China

年份：2024

卷号：146

期号：1

外文期刊名：ASME JOURNAL OF HEAT AND MASS TRANSFER

收录：;EI(收录号：20240515466021);WOS:【SCI-EXPANDED(收录号:WOS:001122652500010)】；

基金：Natural Science Foundation of Shanghai (Grant No.23ZR1416200; Funder ID: 10.13039/100007219).National Natural Science Foundation of China (Grant No.81801795; Funder ID: 10.13039/501100001809).

语种：英文

外文关键词：gold nanorod; prostate cancer; laser ablation; computational model; ex vivo experiment

摘要：The purpose of this study was to develop a computational model for the laser ablation (LA) of prostate cancer, enhanced by gold-nanorods (GNRs) in a phantom-tissue system, and to explore the effect of GNRs on the ablation zone. A prostate biomimetic tissue (PBT) was prepared with different volume fractions of GNRs (i.e., 0, 1.68 x 10-7 or 8.40 x 10-7). Specifically, the computational model was built by considering the change of light properties of PBTs with and without GNRs and introducing the dynamic heat source determined by porcine liver carbonization, reported elsewhere. The computational model was then validated by comparing the simulation and the ex vivo LA experiment in terms of three performance indexes, namely, (i) the spatiotemporal temperature distribution, (ii) ablation zone, and (iii) carbonization zone, with the three volume fractions of GNRs in the PBT model, as mentioned above. Except for minor discrepancies found in the carbonization zone, the proposed model agrees with the experimental data. The effect of GNRs on LA was explored with the help of the model, and nine combinations of the laser powers and the volume fractions of GNRs were tested. The result shows that the ablation zone increases with the increase in the volume fraction of GNRs for all three laser powers used. Two conclusions can be drawn: (1) loading GNRs into the tissues may increase the ablation zone of LA, and (2) the proposed computational model is a reliable tool for predicting the spatiotemporal temperature distribution and the ablation zone of the GNR-enhanced LA.