文献类型：期刊文献

中文题名：脂组学及其研究进展

英文题名：Recent Advances in Lipidomics

作者：朱超[1,2];胡坪[3];梁琼麟[2];王义明[2];罗国安[2]

机构：[1]华东理工大学药学院,上海200237;[2]清华大学化学系,北京100084;[3]华东理工大学化学与分子工程学院,上海200237

年份：2009

卷号：37

期号：9

起止页码：1390

中文期刊名：分析化学

外文期刊名：Chinese Journal of Analytical Chemistry

收录：CSTPCD;;Scopus;WOS:【SCI-EXPANDED(收录号:WOS:000270400500029)】；北大核心:【北大核心2008】；CSCD:【CSCD2011_2012】；

基金：国家自然科学基金项目(Nos.20805026;90707045);国家973项目(Nos.2007CB511903;2007CB714505;2005CB523503)资助

语种：中文

中文关键词：脂组学;脂质分析;电喷雾离子化质谱;代谢组学;评述

外文关键词：Lipidomics; lipid analysis; electrospray ionization mass spectrometry; metabonomics; review

摘要：脂质的生物功能具有多样性,其代谢与多种疾病的发生、发展密切相关。脂质的分析量化对研究疾病发生机理和诊断治疗,以及医药研发有非常重要的生物学意义。分析技术的快速发展,特别是质谱及其联用技术的运用,促使脂质分析不断完善。脂组学就是对生物样本中脂质的整体分析,是代谢组学的重要组成部分,能够促进代谢组学的发展。本文就脂质的生物功能、脂质分析以及脂组学的研究现状作简要评述。
Lipids,which have various biological functions,are closely related to the nosogenesis and aggravation of many diseases.Both qualitative and quantitative determinations of lipids have all-important biological significance in disease diagnosis and treatment,as well as in drug research and development.With the development of analytical technique,especially chromatography combined with mass spectrometry,lipid research is being improved more quickly.Lipidomics is a sub-emerging field of metabonomics research,and could promote the development of metabonomics.In this article,the biological function and analysis of lipid,as well as recent advances in lipidomics are reviewed.